Reversed forks must be protected from uncontrolled nucleolytic degradation. Xie et al. reveal a collaborative defense mechanism orchestrated by Myb/SANT-like DNA-binding domain-containing protein 4 and the breast cancer susceptibility proteins (BRCA1/2)–DNA repair protein RAD51 pathway, which synergistically preserve the integrity of reversed forks.
- Haihua Xie
- Lizhi Song
- Ting Liu
