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Single-cell and spatial profiling reveal cDC2A-CXCL13⁺CD8⁺ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus

The immune microenvironment of lichen planus remains poorly understood. By analyzing transcriptomics and proteomics data on samples from patients and healthy controls, the authors here show that cDC2A secreted IL-15 mediates CXCL13⁺CD8⁺ T to upregulate TNFRSF9 expression which contributes to epithelial cytotoxicity in cutaneous and mucosal LP.

Rundong Jiang
Rachael Bogle
Johann E. Gudjonsson
ResearchOpen Access14 Mar 2026
Nature Communications

Volume: 17, P: 1-15
Discovery of selective low molecular weight interleukin-36 receptor antagonists by encoded library technologies

IL-36 receptor is crucial for host defense and tissue repair. Here, the authors describe identification and characterization of low molecular weight inhibitors of the IL-36 receptor using encoded library technologies. This represents a rare example of small molecules inhibiting a member of IL-1 receptor family.

Juraj Velcicky
Gregor Cremosnik
Georg Martiny-Baron
ResearchOpen Access15 Feb 2025
Nature Communications

Volume: 16, P: 1-13
Design of a Variant of Vascular Endothelial Growth Factor-A (VEGF-A) Antagonizing KDR/Flk-1 and Flt-1

William Leenders
Nicolette Lubsen
Robert de Waal
Research01 Apr 2002
Laboratory Investigation

Volume: 82, P: 473-481
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

The authors uncover a role for the tyrosine phosphatase SHP2 in the propagation and maintenance of breast cancer tumor initiating cells. This role of SHP2 contributes to the growth and metastasis of tumors in vivo and is mediated by a newly uncovered downstream pathway that, through regulation of ERK, modulates the activity of transcription factors such as ZEB1 and Myc, also affecting microRNAs such as let-7. A genetic signature of SHP2 activation is indicative of increased aggressiveness in human breast cancers.

Nicola Aceto
Nina Sausgruber
Mohamed Bentires-Alj
Research04 Mar 2012
Nature Medicine

Volume: 18, P: 529-537

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Single-cell and spatial profiling reveal cDC2A-CXCL13+CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus

Discovery of selective low molecular weight interleukin-36 receptor antagonists by encoded library technologies

Design of a Variant of Vascular Endothelial Growth Factor-A (VEGF-A) Antagonizing KDR/Flk-1 and Flt-1

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

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Single-cell and spatial profiling reveal cDC2A-CXCL13⁺CD8⁺ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus