Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Georgios N. Hatzopoulos Clear advanced filters

  • CenSpark is a dual-ligand fluorescent probe binding simultaneously inner and outer microtubule sites, a configuration unique to doublet and triplet microtubules, enabling selective live imaging of centrioles and cilia across species.

    • Cédric Pourroy
    • Georgios N. Hatzopoulos
    • Pierre Gönczy
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-11

  • Centriole biogenesis begins with self-assembly of SAS-6 proteins into 9-fold symmetrical ring polymers, which then stack into a cartwheel that scaffolds organelle formation. Here, the authors develop monobodies against Chlamydomonas reinhardtii SAS-6 and use X-ray crystallography, atomic force microscopy and cryo-electron microscopy to reveal insights into ring assembly and stacking.

    • Georgios N. Hatzopoulos
    • Tim Kükenshöner
    • Pierre Gönczy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

    • Martin Pacesa
    • Lennart Nickel
    • Bruno E. Correia
    ResearchOpen Access
    Nature
    Volume: 646, P: 483-492

  • Microtubules carry patterns of post-translational modifications that are important for the regulation of key cellular processes. Now a semi-synthetic method facilitates the production of tubulins with defined post-translational modifications. Using these designer tubulins, polyglutamylation of α-tubulin is found to promote its detyrosination by enhancing the activity of the carboxypeptidase vasohibin/small vasohibin-binding protein.

    • Eduard Ebberink
    • Simon Fernandes
    • Charlotte Aumeier
    Research
    Nature Chemistry
    Volume: 15, P: 1179-1187

  • The centriole exhibits an evolutionarily conserved 9-fold radial symmetry that stems from a cartwheel containing vertically stacked ring polymers that harbor 9 homodimers of the protein SAS-6. Here the authors show how dual properties inherent to surface-guided SAS-6 self-assembly possess spatial information that dictates correct scaffolding of centriole architecture.

    • Niccolò Banterle
    • Adrian P. Nievergelt
    • Pierre Gönczy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14