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Showing 1–3 of 3 results
Advanced filters: Author: Gerard J. J. Boink Clear advanced filters

  • Genomic deletions upstream of PITX2 are strongly associated with atrial fibrillation, the most common cardiac arrhythmia. Here, the authors report that ectopic PITX2 expression dosage-dependently disrupts pacemaker cell state and function, and atrial rhythm, linking chromatin conformation of the PITX2 locus to both sinus node dysfunction and atrial fibrillation.

    • Lieve E. van der Maarel
    • M. Ridwane Mungroo
    • Vincent M. Christoffels
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Bouwman et al. identify Hmga1-mediated chromatin remodeling as the fundamental regulator of zebrafish cardiac regeneration and reveal the potential of Hmga1 to restore heart repair in mice by reactivating developmental genes, suggesting potential therapeutic applications.

    • Mara Bouwman
    • Dennis E. M. de Bakker
    • Jeroen Bakkers
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 64-82

  • In this Review, Christoffels and colleagues detail the transcriptional networks that control development and homeostasis of the cardiac conduction system. The pathophysiological consequences of aberrations in these networks are also discussed, with potential insights into the generation of biological pacemakers.

    • Vincent W. W. van Eif
    • Harsha D. Devalla
    • Vincent M. Christoffels
    Reviews
    Nature Reviews Cardiology
    Volume: 15, P: 617-630