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Showing 1–27 of 27 results
Advanced filters: Author: German Sastre Clear advanced filters

  • Cellular Z-RNAs generated during active virus infections are bona fide ZBP1 ligands, and position ZBP1-activated cell death as a host response to counter viral disruption of the cellular transcriptional machinery.

    • Chaoran Yin
    • Aleksandr Fedorov
    • Siddharth Balachandran
    ResearchOpen Access
    Nature
    Volume: 648, P: 707-716

  • This study identifies regulators of the RNA sensor RIG-I. Diverse processes, including the unfolded protein response, Wnt signalling and RNA metabolism, modulate this pathway. The splicing regulator KHSRP is identified as a negative regulator of RIG-I that affects influenza replication in vivo.

    • Stephen Soonthornvacharin
    • Ariel Rodriguez-Frandsen
    • Sumit K. Chanda
    Research
    Nature Microbiology
    Volume: 2, P: 1-13

  • PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunotherapeutic approaches for treatment.

    • Pinar Ayata
    • Jessica M. Crowley
    • Anne Schaefer
    ResearchOpen Access
    Nature
    Volume: 648, P: 157-165

  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436

  • Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.

    • Mitchell J. Machiela
    • Thomas G. P. Grünewald
    • Olivier Delattre
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • In this study, the authors show that that oncogenic hijacking of PRC1 sensitizes genomically stable Ewing sarcoma cells for PLK1 inhibition alone or in synergy with a microtubule-destabilizing drug via induction of cytokinesis defects, rendering PRC1 a promising, broadly applicable predictive biomarker

    • Jing Li
    • Shunya Ohmura
    • Thomas G. P. Grünewald
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

    • Itziar de Rojas
    • Sonia Moreno-Grau
    • Agustín Ruiz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • A computer algorithm discovers all valid combinations of zeolite pairs that form intergrowths and correctly predicts their experimental feasibility.

    • German Sastre
    News & Views
    Nature Materials
    Volume: 24, P: 1875-1876

  • Virus-induced senescence is a central pathogenic feature in COVID-19, and senolytics, which promote apoptosis of senescent cells, can reduce disease severity in hamsters,mice, as well as humans infected with SARS-CoV-2.

    • Soyoung Lee
    • Yong Yu
    • Clemens A. Schmitt
    Research
    Nature
    Volume: 599, P: 283-289

  • Enantiopure zeolites are sought for enantioselective catalytic and separation processes. Here, the authors use chiral organic structure directing agents derived from sugars, guiding the crystallization process toward enantiomorphically pure S-STW zeolites.

    • Andrés Sala
    • José L. Jordá
    • Susana Valencia
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8

  • Activation of the ligand-inducible transcription factor peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to suppress inflammation in peripheral macrophages and in models of human autoimmune disease. As Heneka et al. discuss in this Review, PPARγ is now being investigated as a potential therapeutic target in CNS disorders with an inflammatory component, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis.

    • Michael T Heneka
    • Gary E Landreth
    • Michael Hüll
    Reviews
    Nature Clinical Practice Neurology
    Volume: 3, P: 496-504

  • A diverse, multidisciplinary panel of 386 experts in COVID-19 response from 112 countries provides health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

    • Jeffrey V. Lazarus
    • Diana Romero
    • Anne Øvrehus
    ResearchOpen Access
    Nature
    Volume: 611, P: 332-345

  • Lower olefins are mainly produced from fossil resources and the methanol-to-olefins process offers a new sustainable pathway. Here, the authors show a new zeolite containing tantalum and aluminium centres which shows simultaneously high propene selectivity, catalytic activity, and stability for the synthesis of propene.

    • Longfei Lin
    • Mengtian Fan
    • Sihai Yang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • The differences in virus-host interactions resulting in distinct pathogenicity of seasonal and pandemic influenza A viruses (IAV) are not well understood. Here, the authors show that the hemagglutinin segment from pandemic, but not seasonal, IAV suppresses RIPK3-mediated dendritic cell death, thereby reducing T cell activation.

    • Boris M. Hartmann
    • Randy A. Albrecht
    • Stuart C. Sealfon
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Zeolitic catalyst particles are grown with nanosized fins that improve mass transport into the interior of the particle. This delays catalyst deactivation in the methanol-to-hydrocarbons process.

    • German Sastre
    News & Views
    Nature Materials
    Volume: 19, P: 1040-1041

  • The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

    • Marciela M. DeGrace
    • Elodie Ghedin
    • Mehul S. Suthar
    Reviews
    Nature
    Volume: 605, P: 640-652

  • This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet and infections, and host-intrinsic factors, such as the activity of microglial cells and other immune, vascular and neuronal cell populations, on disease development. They also highlight emerging drugs that target this inflammatory component for therapy of Alzheimer disease.

    • Michael T. Heneka
    • Wiesje M. van der Flier
    • Sean-Patrick Riechers
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 321-352

  • Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

    • Rebecca Sims
    • Sven J van der Lee
    • Gerard D Schellenberg
    Research
    Nature Genetics
    Volume: 49, P: 1373-1384

  • The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.

    • César Muñoz-Fontela
    • William E. Dowling
    • Dan H. Barouch
    Reviews
    Nature
    Volume: 586, P: 509-515