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Showing 1–3 of 3 results
Advanced filters: Author: Gerone A. Gonzales Clear advanced filters

  • Castro-Dopico et al. report the design of reagents to bridge F-actin and Fcγ receptors, endowing a range of antigen-presenting cells with the ability to cross-present antigens from dead tumor cells and boosting antitumor immunity in preclinical models.

    • Tomás Castro-Dopico
    • Cécile Piot
    • Caetano Reis e Sousa
    ResearchOpen Access
    Nature Cancer
    P: 1-18

  • Genomic and transcriptomic analysis of samples from patients with multiple myeloma, followed by in vitro validation, indicate mechanisms of antigen escape in response to GPRC5D T cell-engager talquetamab, including biallelic deletions, small nucleotide variants, insertion-deletions and chromatin silencing.

    • Holly Lee
    • Sungwoo Ahn
    • Nizar J. Bahlis
    ResearchOpen Access
    Nature Medicine
    Volume: 32, P: 964-977

  • The role of non-cancer cells infected by oncolytic viruses (OV) in cancer regression remains elusive. Here the authors engineer OV-sensitive and OV-resistant cancer cell lines and show that OV infection of non-cancer cells can elicit effective antitumour immunity via enhancing DC function and CD8+ T cell activation.

    • Jahanara Rajwani
    • Daniil Vishnevskiy
    • Douglas J. Mahoney
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20