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Nanoporous metals offer the potential for tunability of electronic and optical properties. Here, the authors combine experimental studies and theoretical modeling to explore how nanoporous morphology shapes the intraband and interband contributions to the optical response of gold.

Neo et al. map blood emergence from three hemogenic endothelial (HE) populations biased toward distinct blood fates. HE primed for stem progenitors shows elevated chromatin and RNA splicing gene expression and greater isoform diversity.

In the proof-of-concept phase 2 ROME trial, comprehensive genomic profiling followed by molecular tumor board evaluation and randomization of patients with metastatic solid cancer to receive personalized therapy or standard of care led to a significantly higher objective response rate and longer progression-free survival in patients who received personalized therapy.

In this work, Milano et al. show that neuromorphic nanowire networks are stochastic dynamical systems where dynamics can be holistically described as an Ornstein-Uhlenbeck process, enabling the investigation of the role of deterministic trajectories and stochastic effects on their computational capabilities in the framework of physical reservoir computing.

Understanding species’ spatiotemporal dynamics is key to predicting their responses to climate change. Here, the authors combine landscape genomics, demographic reconstructions, and species distribution models to assess lineage-specific responses to past and future climate in a migratory raptor.

How brain networks organize and interact based on their hierarchical position remains poorly understood. Momi, Wang et al find that high-order brain networks show stronger responses to stimulation and greater dependence on recurrent feedback compared to low-order networks.

An analysis of the EPIC study demonstrates that dietary plant biodiversity presents benefits for human and planetary health, but adverse environmental impacts are associated with dietary animal species richness.

Nanoionic memristive devices achieve stable quantum conductance at room temperature, enabling SI-traceable resistance standards and advancing self-calibrating electronics toward the implementation of national metrology institute services on chip.

A network of self-organized nanowires combined with a memristive read-out layer is used to demonstrate a hardware implementation of reservoir computing for recognition of spatio-temporal patterns and time-series prediction.

Memristors have become an emerging technology capable in emulating human brain information processing, but understanding and controlling the switching mechanism remains elusive. Here, Milano et al. combine memristive and neuromorphic functionalities in a single crystalline nanowire model system.

Physical unclonable functions have been proposed to overcome limitations of current anti-counterfeiting technologies. Here, the authors report the development of nanoscale artificial fingerprints as physical unclonable functions for secure authentication and identification.

Flying humanoid robots face challenges in modelling and control, particularly with aerodynamic forces. Antonello Paolino and colleagues propose the mechanical design of iRonCub-Mk1, a jet-powered humanoid robot, and a methodology to estimate, validate, and control aerodynamic forces during flight.

The role of metabolism in acute myeloid leukaemia (AML) onset remains to be explored. Here, the authors explore the metabolic landscape of AML cells and the signature of extracellular vesicles (EVs) in peripheral blood and show that circulating EVs regulate leukaemia (stem) cell metabolic reprogramming.

The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if deleted, affects renal tubules morphogenesis in various organisms.

Hardware architectures based on self-organized memristive networks of nano objects have attracted a growing attention. Here, nanowire connectomes are experimentally proved to translate spatially correlated short-term plasticity effects into long-lasting topological changes, thus emulating both information encoding and memory consolidation of human brain.

Faecal microbiota transplantation (FMT) is becoming a therapeutic option in several gastrointestinal disorders. Here, Burrello et al. study the immunological mechanisms by which FMT reduces colonic inflammation and initiates the restoration of intestinal homeostasis in a mouse model of colitis.

Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.

An ideal optical frequency-comb system should combine both single-line spectral resolution and a bandwidth broad enough to cover as many lines as possible. Here, the authors incorporate a fibre spectrometer to detect approximately 500 comb-lines with an instrument resolution of 120 megahertz.

The therapeutic options for castration-resistant prostate cancer (CRPC) remain limited. Here, the authors highlight the role of methionine adenosyltransferase 2a (MAT2A) in epigenetic reprogramming and suggest its therapeutic targeting in CRPC.

Genome-wide association analyses identify 30 risk loci for IgA nephropathy. Functional annotations of putative causal genes converge on inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.

It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

In a phase 2 trial, monitoring tumor resistance mutations in blood using liquid biopsies allowed rationally guided subsequent therapy with anti-EGFR antibodies in patients with colorectal cancer.

Accurate interpretation of molecular vibrational spectroscopic signals is key to understand chemical processes. Here the authors introduce a new computational approach to represent vibrational modes in terms of nuclear densities that captures anharmonic effects in protonated glycine.

Introduction of a diffractive axicon in a pulse shaper enables imparting topological–spectral correlation to ultrafast pulses over 200 nm in the visible region and with topological charges up to 80.

Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset.

Using whole-genome data for single-nucleotide polymorphism and results from genome-wide association studies, the authors show that people’s preference for pairing with those with similar phenotypic traits has genetic causes and consequences.

With increasing neutron number, the size of a nucleus grows, subject to subtle effects that act as fingerprints of its internal structure. A fresh look at potassium calls for theory to decipher the details.

Three key axes of variation of ecosystem functional changes and their underlying causes are identified from a dataset of surface gas exchange measurements across major terrestrial biomes and climate zones.

First-line platinum and taxane chemotherapy improves the prognosis of patients with epithelial ovarian cancer (EOC), however, about 80% of patients relapse and long-term survival is poor. The development of drug resistance is the main cause of treatment failure; therefore, the identification of new compounds that interfere with tumor growth and survival is a priority.

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.

Systemic sclerosis (SSc) is a heterogeneous chronic autoimmune disease that affects the connective tissue. Here, López-Isac et al. identify 13 new risk loci for SSc as well as loci specific for limited cutaneous and diffuse SSc and, defining credible sets and performing functional annotation, highlight key pathways and cell types for SSc.