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Advanced filters: Author: Gilbert Mchantaf Clear advanced filters

HIV persistence in tissues on dolutegravir-based therapy is not associated with resistance mutations to dolutegravir

Mchantaf et al. explore HIV-1 persistence in five anatomical compartments in people living with HIV on successful Dolutegravir therapy. They find the highest levels of infection and viral transcription in lymph nodes, and that persistence is not associated with the selection of drug resistance mutations to Dolutegravir.

Gilbert Mchantaf
Adeline Melard
Véronique Avettand-Fenoel
ResearchOpen Access27 Jan 2026
Communications Medicine

P: 1-10
Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency

In their study, Dorman and Bendoumou et al., reveal a post-transcriptional regulation of unspliced HIV-1 RNA by host factors MATR3, MTR4, and the viral protein Rev, identifying a previously uncharacterized post-transcriptional block in nucleocytoplasmic export, which plays a crucial role in HIV-1 latency and reactivation.

Agnieszka Dorman
Maryam Bendoumou
Anna Kula-Pacurar
ResearchOpen Access28 Feb 2025
Nature Communications

Volume: 16, P: 1-15
Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

Christine Durier
Laetitia Ninove
Florent Valour
ResearchOpen Access27 Nov 2022
Scientific Reports

Volume: 12, P: 1-10

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