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Nature Immunology (3)

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Advanced filters: Author: Gildas Lepennetier Clear advanced filters

CD38 endows local antigen-specific T_reg cells with stress resilience for control of compartmentalized CNS inflammation

Here, the authors use a mouse model of multiple sclerosis to show that CD38⁺Foxp3⁺ T_reg cells persist in postinflammatory CNS tissues and are needed for maintaining immune homeostasis. These localized stress-tolerant T_reg cells have developed mechanisms to exploit the limited availability of IL-2 in this tissue.

Hsin-Hsiang Chen
Sofia Tyystjärvi
Thomas Korn
ResearchOpen Access29 Jan 2026
Nature Immunology

Volume: 27, P: 516-529
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity

Korn and colleagues demonstrate that the site of T cell priming (gut versus skin draining lymph nodes) dictates their effector phenotypes and homing to distal sites of immunopathology.

Michael Hiltensperger
Eduardo Beltrán
Thomas Korn
Research07 Jun 2021
Nature Immunology

Volume: 22, P: 880-892
Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity

Korn and colleagues show that PMN-MDSCs restrain B cell accumulation in the central nervous system in autoimmune inflammation.

Benjamin Knier
Michael Hiltensperger
Thomas Korn
Research29 Oct 2018
Nature Immunology

Volume: 19, P: 1341-1351

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