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Showing 1–4 of 4 results
Advanced filters: Author: Gilles Bessou Clear advanced filters

  • Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.

    • Clemence Ngo
    • Camille Pierini-Malosse
    • Elena Tomasello
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 1962-1976

  • Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN-I). Dalod and colleagues show that IFN-I production and T cell activation were performed by the same pDC, but these occurred sequentially and in different micro-anatomical locations during virus infection.

    • Abdenour Abbas
    • Thien-Phong Vu Manh
    • Elena Tomasello
    Research
    Nature Immunology
    Volume: 21, P: 983-997

  • Reis e Sousa et al. show that cDC2As and cDC2Bs are derived from distinct subsets of bone marrow pre-cDC2s, suggesting that the two lineages are ontogenetically determined.

    • Carlos M. Minutti
    • Cécile Piot
    • Caetano Reis e Sousa
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 448-461

  • Dalod and colleagues utilize a combinatorial genetic reporter strategy to uniquely mark plasmacytoid dendritic cells (pDCs) in mice. They utilize these mice to identify bona fide pDCs and functionally characterize before and during viral infection, in comparison to several other DC types.

    • Michael Valente
    • Nils Collinet
    • Marc Dalod
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 714-728