Nature Search

Molecular recognition of thyroglobulin by sortilin

Sortilin mediates thyroglobulin endocytosis within the thyroid. Using structural biology, the authors reveal that sortilin acts as structural sensor of monomeric thyroglobulin, independently of its iodination and hormone content, via binding of a flexible C-terminal peptide.

Irene Boniardi
Giorgia Tanzi
Francesca Coscia
ResearchOpen Access24 Jan 2026
Nature Communications

P: 1-14
Italian labs shape-shift to fight the pandemic

Wanting to contribute, and share in the spree, scientists from all fields have refocused expertise and equipment to study COVID-19

Giorgia Guglielmi
News21 Nov 2020
Nature Italy
I laboratori italiani si reinventano contro la pandemia

Desiderio di contribuire e nuovi finanziamenti spingono scienziati dai campi più diversi a riorientare competenze e attrezzature per studiare il COVID-19

Giorgia Guglielmi
News21 Nov 2020
Nature Italy
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Ras is involved in nerve-activity-dependent regulation of muscle genes

Marta Murgia
Antonio L. Serrano
Stefano Schiaffino
Research04 Feb 2000
Nature Cell Biology

Volume: 2, P: 142-147
Molecular mechanism of thyroxine transport by monocarboxylate transporters

Structural biology approaches are used to show how thyroxine is transported by monocarboxylate transporters (MCT)8 and 10, and MCT8 inhibition by silychristin. These findings shed light on how a MCT8 patient-derived mutation alters its function.

Matteo Tassinari
Giorgia Tanzi
Francesca Coscia
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-11
Two subsets of stem-like CD8⁺ memory T cell progenitors with distinct fate commitments in humans

The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T cells—one giving rise to a functional lineage, the other to an exhausted-like one.

Giovanni Galletti
Gabriele De Simone
Enrico Lugli
Research12 Oct 2020
Nature Immunology

Volume: 21, P: 1552-1562
Printing glass in the nano

A transparent suspension containing colloidal silica is used to additively manufacture three-dimensional structures and photonic devices of silica glass at the nanoscale.

Paolo Colombo
Giorgia Franchin
News & Views25 Oct 2021
Nature Materials

Volume: 20, P: 1454-1456
A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis

In patients with cystic fibrosis, IL-9 signalling is increased. The authors describe an inflammatory loop in which IL-9 produced by Th9 cells drives mast cells to produce IL-2, resulting in ILC2 cell activation, and show inhibition of this loop with blocking antibodies to IL-9 in a mouse model of pulmonary infection.

Silvia Moretti
Giorgia Renga
Luigina Romani
ResearchOpen Access16 Jan 2017
Nature Communications

Volume: 8, P: 1-13
Clonally expanded EOMES⁺ Tr1-like cells in primary and metastatic tumors are associated with disease progression

Human primary and metastatic tumors harbor CD4⁺ T_reg cells that can suppress antitumor immune responses. Bonnal et al. identify an intratumoral type 1 T_reg-like CD4⁺ T cell subset that expresses the transcription factor EOMES, granzyme K and CHI3L2. This EOMES⁺ T cell subset correlates with disease progression but is responsive to PD-1 checkpoint blockade immunotherapy.

Raoul J. P. Bonnal
Grazisa Rossetti
Massimiliano Pagani
Research20 May 2021
Nature Immunology

Volume: 22, P: 735-745
Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary

G Mangili
J Ottolina
D Lorusso
ResearchOpen Access11 Jun 2013
British Journal of Cancer

Volume: 109, P: 29-34
Ag- or Cu-modified geopolymer filters for water treatment manufactured by 3D printing, direct foaming, or granulation

Tero Luukkonen
Juho Yliniemi
Paolo Colombo
ResearchOpen Access29 Apr 2020
Scientific Reports

Volume: 10, P: 1-14
Extracellular vesicles from the microalga Tetraselmis chuii are biocompatible and exhibit unique bone tropism along with antioxidant and anti-inflammatory properties

This study highlights the biocompatibility, tropism, antioxidant and anti-inflammatory properties of nanoalgosomes, extracellular vesicles (EVs) derived from the marine microalga Tetraselmis chuii, suggesting their potential for EV-based therapies.

Giorgia Adamo
Pamela Santonicola
Antonella Bongiovanni
ResearchOpen Access03 Aug 2024
Communications Biology

Volume: 7, P: 1-17
Author Correction: Intra-specific variation in sensitivity of Bombus terrestris and Osmia bicornis to three pesticides

Alberto Linguadoca
Margret Jürison
Mark J. F. Brown
Amendments and CorrectionsOpen Access06 Dec 2022
Scientific Reports

Volume: 12, P: 1
Author Correction: Single-cell profiling defines the prognostic benefit of CD39^high tissue resident memory CD8+ T cells in luminal-like breast cancer

Agnese Losurdo
Caterina Scirgolea
Enrico Lugli
Amendments and CorrectionsOpen Access27 Oct 2021
Communications Biology

Volume: 4, P: 1
Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis

Curcumin-based fluorescent probes are presented that are able to selectively bind to aldehyde dehydrogenase 1A3 (ALDH1A3), an enzyme overexpressed in glioma stem cells and specifically identify glioblastoma cells in vitro and in vivo.

Edoardo L. M. Gelardi
Diego Caprioglio
Silvia Garavaglia
ResearchOpen Access01 Sept 2022
Communications Biology

Volume: 5, P: 1-14
Intra-specific variation in sensitivity of Bombus terrestris and Osmia bicornis to three pesticides

Alberto Linguadoca
Margret Jürison
Mark J. F. Brown
ResearchOpen Access15 Oct 2022
Scientific Reports

Volume: 12, P: 1-12
Single-cell profiling defines the prognostic benefit of CD39^high tissue resident memory CD8+ T cells in luminal-like breast cancer

Losurdo et al analyze breast cancer-infiltrating T cells by single-cell technologies . The find that the extent of infiltration of a small subset of tissue-resident memory CD8+ T cells identify patients with improved survival, highlighting the importance of the specific T cell immune microenvironment.

Agnese Losurdo
Caterina Scirgolea
Enrico Lugli
ResearchOpen Access22 Sept 2021
Communications Biology

Volume: 4, P: 1-11
Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism

Arianna Bettiga
Massimo Aureli
Fabio Benigni
ResearchOpen Access13 Feb 2017
Scientific Reports

Volume: 7, P: 1-11
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry

This protocol describes the design, application and computational analysis of high-dimensional fluorescent antibody panels for flow cytometry. Up to 28 colors can be characterized to study complex cellular populations such as the immune system.

Jolanda Brummelman
Claudia Haftmann
Enrico Lugli
Protocols03 Jun 2019
Nature Protocols

Volume: 14, P: 1946-1969
Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit^W-sh/W-sh mice

Silvia Piconese
Massimo Costanza
Rosetta Pedotti
Research14 Feb 2011
Laboratory Investigation

Volume: 91, P: 627-641
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Molecular recognition of thyroglobulin by sortilin

Italian labs shape-shift to fight the pandemic

I laboratori italiani si reinventano contro la pandemia

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Ras is involved in nerve-activity-dependent regulation of muscle genes

Molecular mechanism of thyroxine transport by monocarboxylate transporters

Two subsets of stem-like CD8⁺ memory T cell progenitors with distinct fate commitments in humans

Printing glass in the nano

A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis

Clonally expanded EOMES⁺ Tr1-like cells in primary and metastatic tumors are associated with disease progression

Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary

Ag- or Cu-modified geopolymer filters for water treatment manufactured by 3D printing, direct foaming, or granulation

Extracellular vesicles from the microalga Tetraselmis chuii are biocompatible and exhibit unique bone tropism along with antioxidant and anti-inflammatory properties

Author Correction: Intra-specific variation in sensitivity of Bombus terrestris and Osmia bicornis to three pesticides

Author Correction: Single-cell profiling defines the prognostic benefit of CD39^high tissue resident memory CD8+ T cells in luminal-like breast cancer

Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis

Intra-specific variation in sensitivity of Bombus terrestris and Osmia bicornis to three pesticides

Single-cell profiling defines the prognostic benefit of CD39^high tissue resident memory CD8+ T cells in luminal-like breast cancer

Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry

Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit^W-sh/W-sh mice

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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