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A procedure for rule extraction from a Self-Organising plasma disruption predictor for JET

Samuele Setzu
Enrico Aymerich
I. Zychor
ResearchOpen Access10 Apr 2026
Scientific Reports

P: 1-21
Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in the tumor microenvironment

The tumor microenvironment influences the metabolic behavior of cancer cells. Here, using Dual Ribosome Profiling, the authors uncover a cancer-stromal cell interaction under glucose starvation that increases nutrient availability, in response to type I interferon. In addition, in vivo, immune checkpoint blockade triggers metabolic constraints in T cells, reducing their proliferation and cytotoxicity.

Daniela Aviles-Huerta
Rossella Del Pizzo
Fabricio Loayza-Puch
ResearchOpen Access19 May 2025
Nature Communications

Volume: 16, P: 1-14
Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia

Here, the authors show how in β-thalassemia, a perturbed bone marrow microenvironment leads to altered hematopoiesis. Reduced TGFβ reduces autophagy levels, in turn reducing dormancy and priming of haematopoietic stem cells and multipotent progenitors towards erythroid lineage.

Maria Rosa Lidonnici
Giulia Chianella
Giuliana Ferrari
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Silencing Nfix rescues muscular dystrophy by delaying muscle regeneration

Strategies aimed at promoting muscle regeneration to treat muscular dystrophy have met with limited success. Here the authors show instead that delaying muscle regeneration, by ablation of the transcription factor Nfix, ameliorates muscular dystrophy in mice.

Giuliana Rossi
Chiara Bonfanti
Graziella Messina
ResearchOpen Access20 Oct 2017
Nature Communications

Volume: 8, P: 1-12
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

Jessica Zucman-Rossi and colleagues report exome sequencing of 24 hepatocellular carcinomas and non-tumor liver tissues and copy-number analysis of 125 tumors. They identify new recurrent mutations in ARID1A, RPS6KA3, NFE2L2 and IRF2 in HCC.

Cécile Guichard
Giuliana Amaddeo
Jessica Zucman-Rossi
Research06 May 2012
Nature Genetics

Volume: 44, P: 694-698
Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress

Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to display replication stress-induced structural rearrangements frequently activating TERT promoter.

Quentin Bayard
Léa Meunier
Eric Letouzé
ResearchOpen Access07 Dec 2018
Nature Communications

Volume: 9, P: 1-14
Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia

In a phase 1/2 clinical trial, gene therapy with autologous hematopoietic stem cells significantly reduced transfusion requirement in adults and children with transfusion dependent ß-thalassemia.

Sarah Marktel
Samantha Scaramuzza
Giuliana Ferrari
Research21 Jan 2019
Nature Medicine

Volume: 25, P: 234-241
Prevention of obesity in toddlers (PROBIT): a randomised clinical trial of responsive feeding promotion from birth to 24 months

Anita Morandi
Mara Tommasi
Claudio Maffeis
Research03 Jul 2019
International Journal of Obesity

Volume: 43, P: 1961-1966
Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution

Giuliana Rossi
Sonja Giger
Matthias P. Lutolf
ResearchOpen Access04 Aug 2022
Scientific Reports

Volume: 12, P: 1-12
PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence

Mesoangioblasts are mesodermal stem cells with a therapeutic potential for treatment of muscular dystrophy due to their ability to differentiate into skeletal muscle. This study shows that the PW1/Peg3 protein is crucial for mesoangioblast myogenic and migratory potency and is a therapeutically relevant biomarker.

Chiara Bonfanti
Giuliana Rossi
Graziella Messina
ResearchOpen Access09 Mar 2015
Nature Communications

Volume: 6, P: 1-13
Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells

Fulvio Mavilio
Graziella Pellegrini
Michele De Luca
Research19 Nov 2006
Nature Medicine

Volume: 12, P: 1397-1402
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

Stefano Pluchino
Angelo Quattrini
Gianvito Martino
Research17 Apr 2003
Nature

Volume: 422, P: 688-694
Real life outcome analysis of breast cancer brain metastases treated with Trastuzumab Deruxtecan

Alessandra Fabi
Alessandro Rossi
Andrea Botticelli
ResearchOpen Access22 Jan 2025
npj Precision Oncology

Volume: 9, P: 1-8
Progress and potential in organoid research

Organoids are 3D structures derived from stem cells that recapitulate some key characteristics of real organs. The authors review recent progress in organoid derivation and applications and outline how advances in other disciplines might lead to more physiologically relevant organoids.

Giuliana Rossi
Andrea Manfrin
Matthias P. Lutolf
Reviews18 Sept 2018
Nature Reviews Genetics

Volume: 19, P: 671-687
Drug-related hepatotoxicity risk in elderly patients with atrial fibrillation: insights from the nationwide Italian START registry

Gianluca Gazzaniga
Danilo Menichelli
Gianmarco Podda
ResearchOpen Access31 Dec 2025
Scientific Reports

Volume: 15, P: 1-11
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism

Stefano Pluchino
Lucia Zanotti
Gianvito Martino
Research14 Jul 2005
Nature

Volume: 436, P: 266-271
CPX-351 treatment in secondary acute myeloblastic leukemia is effective and improves the feasibility of allogeneic stem cell transplantation: results of the Italian compassionate use program

Fabio Guolo
Luana Fianchi
Roberto Massimo Lemoli
ResearchOpen Access06 Oct 2020
Blood Cancer Journal

Volume: 10, P: 1-11
Correction: Prevention of obesity in toddlers (PROBIT): a randomised clinical trial of responsive feeding promotion from birth to 24 months

Anita Morandi
Mara Tommasi
Claudio Maffeis
Amendments and Corrections12 Aug 2020
International Journal of Obesity

Volume: 44, P: 2177
Bone metabolism in patients with type 1 neurofibromatosis: key role of sun exposure and physical activity

Ursula Pia Ferrara
Cristina Tortora
Daniela Melis
ResearchOpen Access14 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Transcriptional, epigenetic and retroviral signatures identify regulatory regions involved in hematopoietic lineage commitment

Oriana Romano
Clelia Peano
Annarita Miccio
ResearchOpen Access20 Apr 2016
Scientific Reports

Volume: 6, P: 1-15
Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells

Giovanna Talarico
Stefania Orecchioni
Francesco Bertolini
ResearchOpen Access05 Jan 2016
Scientific Reports

Volume: 6, P: 1-10
Multidisciplinary studies on a sick-leader syndrome-associated mass stranding of sperm whales (Physeter macrocephalus) along the Adriatic coast of Italy

Sandro Mazzariol
Cinzia Centelleghe
Giovanni Di Guardo
ResearchOpen Access01 Aug 2018
Scientific Reports

Volume: 8, P: 1-18
Clinical trajectories of individuals with severe mental illness continuing and discontinuing long-acting antipsychotics: a one-year mirror-image analysis from the STAR Network Depot study

Giovanni Ostuzzi
Federico Tedeschi
Davide Papola
ResearchOpen Access17 Apr 2023
Schizophrenia

Volume: 9, P: 1-8
Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020

Alessia Lai
Annalisa Bergna
Dario Russignaga
ResearchOpen Access06 Apr 2022
Scientific Reports

Volume: 12, P: 1-12
Prevalence and prognostic significance of microsatellite alterations in young patients with bladder cancer

Mario Migaldi
Giuliana Sartori
Alessandro Sgambato
Research22 Apr 2005
Modern Pathology

Volume: 18, P: 1176-1186

Search

A procedure for rule extraction from a Self-Organising plasma disruption predictor for JET

Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in the tumor microenvironment

Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia

Silencing Nfix rescues muscular dystrophy by delaying muscle regeneration

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress

Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia

Prevention of obesity in toddlers (PROBIT): a randomised clinical trial of responsive feeding promotion from birth to 24 months

Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution

PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence

Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells

Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

Real life outcome analysis of breast cancer brain metastases treated with Trastuzumab Deruxtecan

Progress and potential in organoid research

Drug-related hepatotoxicity risk in elderly patients with atrial fibrillation: insights from the nationwide Italian START registry

Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism

CPX-351 treatment in secondary acute myeloblastic leukemia is effective and improves the feasibility of allogeneic stem cell transplantation: results of the Italian compassionate use program

Correction: Prevention of obesity in toddlers (PROBIT): a randomised clinical trial of responsive feeding promotion from birth to 24 months

Bone metabolism in patients with type 1 neurofibromatosis: key role of sun exposure and physical activity

Transcriptional, epigenetic and retroviral signatures identify regulatory regions involved in hematopoietic lineage commitment

Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells

Multidisciplinary studies on a sick-leader syndrome-associated mass stranding of sperm whales (Physeter macrocephalus) along the Adriatic coast of Italy

Clinical trajectories of individuals with severe mental illness continuing and discontinuing long-acting antipsychotics: a one-year mirror-image analysis from the STAR Network Depot study

Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020

Prevalence and prognostic significance of microsatellite alterations in young patients with bladder cancer

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