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Showing 1–3 of 3 results
Advanced filters: Author: Giusy Russomanno Clear advanced filters

  • Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regulated exosomal miRNAs have a therapeutic effect.

    • Hebah A. Sindi
    • Giusy Russomanno
    • Beata Wojciak-Stothard
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Quantitative systems toxicology (QST) models have the potential to increase confidence in the safety assessment of drug candidates and to inform project progression decisions. This article overviews the fundamentals of constructing and using QST models, presents the state-of-the-art for models of cardiovascular, gastrointestinal, hepatic and renal toxicities, and it provides recommendations for their application in drug discovery and development.

    • Christopher E. Goldring
    • Giusy Russomanno
    • Loic Laplanche
    Reviews
    Nature Reviews Drug Discovery
    Volume: 25, P: 138-153