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Showing 1–8 of 8 results
Advanced filters: Author: Gloria Sheynkman Clear advanced filters

  • This Registered Report presents the results of the Long-read RNA-Seq Genome Annotation Assessment Project, which is a community effort for benchmarking long-read methods for transcriptome analyses, including transcript isoform detection, quantification and de novo transcript detection.

    • Francisco J. Pardo-Palacios
    • Dingjie Wang
    • Angela N. Brooks
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1349-1363

  • Proteoforms are the diverse protein molecules produced from a single gene whose primary sequence and composition can be diversified by genetic, transcriptomic, translational and post-translational variation. This Review synthesizes technologies and network approaches to map, quantify and functionally characterize proteoforms, outlining routes to proteoform-guided biomarkers and therapeutics

    • Jennifer A. Korchak
    • S. Stephen Yi
    • Gloria M. Sheynkman
    Reviews
    Nature Reviews Genetics
    P: 1-21

  • Most human protein-coding genes are expressed as multiple isoforms. Here the authors present ORF Capture-seq that uses cloned ORFs as probes to capture and sequence full length transcript sequences. This enables highly sensitive characterization of eukaryotic transcriptomes.

    • Gloria M. Sheynkman
    • Katharine S. Tuttle
    • Marc Vidal
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • RNA alternative splicing is involved in determining cell identity, but a comprehensive molecular map is missing. Here, the authors provide a human and mouse brain atlas of transcript isoforms linking them to cellular identity, brain regions and development stages.

    • Anoushka Joglekar
    • Wen Hu
    • Hagen U. Tilgner
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 1051-1063

  • A human binary protein interactome map that includes around 53,000 protein–protein interactions involving more than 8,000 proteins provides a reference for the study of human cellular function in health and disease.

    • Katja Luck
    • Dae-Kyum Kim
    • Michael A. Calderwood
    Research
    Nature
    Volume: 580, P: 402-408

  • During blood vessel development, endothelial cells become specified toward arterial or venous fates. Chavkin et al find that distinct endothelial cell cycle states provide windows of opportunity for the molecular induction of arterial or venous fate.

    • Nicholas W. Chavkin
    • Gael Genet
    • Karen K. Hirschi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17