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Showing 1–6 of 6 results

Advanced filters: Author: Gonghui Hu Clear advanced filters

Polypharmacy or potentially inappropriate medications among older adults with COVID-19 in a secondary hospital in China and their association with mortality

Mian Mao
Shan Du
Xiaoli Hu
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
GHS-R1a signaling drives anxiety-related behavior by shaping excitability of ventromedial hypothalamic neurons

The neural substrates of anxiety are poorly understood. Here authors show that VMH αCaMKII⁺ neurons reduce anxiety when stressed. Ghrelin receptor GHS-R1a inhibits these neurons, promoting anxiety. Targeting GHS-R1a may help treat anxiety disorders.

Meng Zhang
Liu Yang
Yu Zhou
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Stress-induced GHS-R1a expression in medial prefrontal cortical neurons promotes vulnerability to anxiety in mice

GHS-R1a acts as a molecular switch which promotes anxiety by altering synaptic activity in mPFC αCaMKII+ neurons, offering new insights into treating stress-induced anxiety disorders.

Liu Yang
Meng Zhang
Yu Zhou
ResearchOpen Access13 Mar 2025
Communications Biology

Volume: 8, P: 1-12
Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression

Linyi Hu
Yin Sun
Chawnshang Chang
ResearchOpen Access20 Nov 2019
Oncogene

Volume: 39, P: 1891-1903
TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals

Jian Bai
Shuyuan Yeh
Chawnshang Chang
Research04 Jul 2018
Oncogene

Volume: 37, P: 5901-5912
LncRNA-SARCC suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(AR)/miRNA-143-3p signals

Wei Zhai
Yin Sun
Chawnshang Chang
Research23 Jun 2017
Cell Death & Differentiation

Volume: 24, P: 1502-1517