Nature Search

Differential GABA dynamics across brain functional networks in autism

Distinct functional networks in the autistic brain respond differently to pharmacological modulation targeting GABA B receptors. This finding offers new insights into the paradoxicality of clinical interventions for autism and provides inspiration for subsequent precision interventions.

Qiyun Huang
Di Chen
Gráinne M. McAlonan
ResearchOpen Access24 Jan 2026
Communications Biology

P: 1-14
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics

This study presents an analytic framework to link imaging-derived brain phenotypes to gene expression. In the future, this approach may facilitate in vivo pharmacotranscriptomics and the development of personalized (pharmacological) interventions.

Christine Ecker
Charlotte M. Pretzsch
Declan G. Murphy
ResearchOpen Access22 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Author Correction: New therapies for systemic lupus erythematosus — past imperfect, future tense

Grainne Murphy
David A. Isenberg
Amendments and Corrections03 Jul 2019
Nature Reviews Rheumatology

Volume: 15, P: 509
Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

Edmond M. Kwan
Sarah W. S. Ng
Alison Y. Zhang
Research27 May 2025
Nature Medicine

Volume: 31, P: 2722-2736
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
SLE-associated arthropathy: truly a benign entity?

Arthropathy is a common manifestation of systemic lupus erythematosus (SLE), but remains poorly understood. Recent ultrasonographic evidence demonstrating high levels of joint and tendon pathology in SLE challenges our previous concepts of arthritis subtypes in this multisystem disease.

Grainne Murphy
David A. Isenberg
News & Views13 Nov 2012
Nature Reviews Rheumatology

Volume: 8, P: 695-696
Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder

Qiyun Huang
Hester Velthuis
Gráinne M. McAlonan
ResearchOpen Access18 Oct 2023
Translational Psychiatry

Volume: 13, P: 1-13
Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy

Charlotte M Pretzsch
Bogdan Voinescu
Gráinne M. McAlonan
ResearchOpen Access20 Nov 2019
Translational Psychiatry

Volume: 9, P: 1-10
Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder

Charlotte Marie Pretzsch
Jan Freyberg
Gráinne M. McAlonan
ResearchOpen Access06 Feb 2019
Neuropsychopharmacology

Volume: 44, P: 1398-1405
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): a randomised placebo-controlled single-dose crossover trial

Nichol M. L. Wong
James L. Findon
Eileen Daly
ResearchOpen Access10 May 2020
Neuropsychopharmacology

Volume: 45, P: 2248-2256
Modulation of brain activation during executive functioning in autism with citalopram

Robert H. Wichers
James L. Findon
Eileen M. Daly
ResearchOpen Access11 Nov 2019
Translational Psychiatry

Volume: 9, P: 1-11
From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

Cornelia Carey
Nisha Singh
Grainne McAlonan
ResearchOpen Access20 Sept 2022
Translational Psychiatry

Volume: 12, P: 1-10
Sensitive tumour detection and classification using plasma cell-free DNA methylomes

An immunoprecipitation-based protocol is developed to analyse DNA methylation in small quantities of circulating cell-free DNA, and can detect and classify cancers in plasma samples from several tumour types.

Shu Yi Shen
Rajat Singhania
Daniel D. De Carvalho
Research14 Nov 2018
Nature

Volume: 563, P: 579-583
Emerging functional connectivity differences in newborn infants vulnerable to autism spectrum disorders

Judit Ciarrusta
Ralica Dimitrova
Grainne McAlonan
ResearchOpen Access06 May 2020
Translational Psychiatry

Volume: 10, P: 1-10
Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen

Lina Schukur
Tamara Zimmermann
Claudio R. Thoma
ResearchOpen Access18 Nov 2020
Scientific Reports

Volume: 10, P: 1-16
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
New therapies for systemic lupus erythematosus — past imperfect, future tense

A series of successive failures of new therapies for systemic lupus erythematosus (SLE) in clinical trials has left clinicians with limited options to treat this disease. Could any of the therapies currently in development offer hope for patients with SLE?

Grainne Murphy
David A. Isenberg
Reviews05 Jun 2019
Nature Reviews Rheumatology

Volume: 15, P: 403-412
Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers

Oliver Gale-Grant
Andrew Chew
Dafnis Batalle
ResearchOpen Access10 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans

Jumana Ahmad
Claire Ellis
Grainne McAlonan
ReviewsOpen Access08 Nov 2022
Translational Psychiatry

Volume: 12, P: 1-12
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder

L A Ajram
J Horder
G M McAlonan
ResearchOpen Access23 May 2017
Translational Psychiatry

Volume: 7, P: e1137

Search

Differential GABA dynamics across brain functional networks in autism

Mapping the human genetic architecture of COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics

Author Correction: New therapies for systemic lupus erythematosus — past imperfect, future tense

Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial

A second update on mapping the human genetic architecture of COVID-19

SLE-associated arthropathy: truly a benign entity?

Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder

Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy

Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): a randomised placebo-controlled single-dose crossover trial

Modulation of brain activation during executive functioning in autism with citalopram

From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

Sensitive tumour detection and classification using plasma cell-free DNA methylomes

Emerging functional connectivity differences in newborn infants vulnerable to autism spectrum disorders

Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen

A first update on mapping the human genetic architecture of COVID-19

New therapies for systemic lupus erythematosus — past imperfect, future tense

Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers

From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder

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