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Showing 1–18 of 18 results
Advanced filters: Author: Greg Lemke Clear advanced filters

    • GREG LEMKE
    Research
    Nature
    Volume: 348, P: 201

  • In this Comment, Greg Lemke and Gregg Silverman propose that the excessive blood clotting and immune activation seen in severe COVID-19 may be mechanistically linked through protein S, a ligand for the immunosuppressive TAM receptor family.

    • Greg Lemke
    • Gregg J. Silverman
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 20, P: 395-396

  • Microglial phagocytosis is required for neurogenic niche maintenance and response to injury; the TAM kinases Mer and Axl are expressed by microglia in the adult CNS, and mediate the clearance of apoptotic cells from the niche.

    • Lawrence Fourgeaud
    • Paqui G. Través
    • Greg Lemke
    Research
    Nature
    Volume: 532, P: 240-244

  • How microglia sense amyloid plaques in Alzheimer’s disease has remained mysterious. Lemke and colleagues report that TAM receptor kinases are absolutely required for normal microglial recognition of, response to and phagocytosis of Aβ plaques. Surprisingly, TAM-mediated microglial phagocytosis of Aβ material does not constrain, but rather promotes, the formation of dense-core plaques.

    • Youtong Huang
    • Kaisa E. Happonen
    • Greg Lemke
    Research
    Nature Immunology
    Volume: 22, P: 586-594

  • In this Review, Greg Lemke explains how macrophages are able to sense and respond to dead and dying cells. The author discusses the physiological implications of such macrophage activity.

    • Greg Lemke
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 539-549

  • The clearance of apoptotic cells requires recognition by members of the TAM receptor tyrosine kinase family. Lemke and colleagues show that the TAM receptors Mer and Axl have distinct functions in tolerance induction and proinflammatory responses, respectively.

    • Anna Zagórska
    • Paqui G Través
    • Greg Lemke
    Research
    Nature Immunology
    Volume: 15, P: 920-928

  • The TAM receptors — TYRO3, AXL and MER — are emerging as important regulators of innate immune responses. Here, the authors describe their roles in inhibiting inflammation driven by antigen-presenting cells, in promoting phagocytosis of apoptotic cells and in stimulating maturation of natural killer cells.

    • Greg Lemke
    • Carla V. Rothlin
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 327-336

  • Growing evidence indicates important roles for microglial phagocytosis in Alzheimer disease. This Review summarizes the latest insights into the mechanisms by which microglial phagocytosis can affect Alzheimer disease pathology and how this process might be harnessed for therapeutic interventions.

    • Guy C. Brown
    • Peter St George-Hyslop
    • Greg Lemke
    Reviews
    Nature Reviews Neurology
    Volume: 22, P: 54-69

  • Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs from patients with rheumatoid arthritis have high levels of miR- 34a.

    • Mariola Kurowska-Stolarska
    • Stefano Alivernini
    • Iain B. McInnes
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13