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RABV upregulates FBXL18, which stabilizes BST2 via K11-linked ubiquitination at Lys109/110, thereby activating NF-κB. FBXL18 knockdown effectively suppresses inflammation and virulence, highlighting its potential as a therapeutic target for rabies.

Dysregulation of blood vessel size can cause vascular malformations. Here, the authors demonstrate that endothelial cells generate circumferential actomyosin cables to control the size of cells and vessels.

Magnesium metal batteries hold great promise for next-generation energy storage but struggle with limited understanding of their deposition mechanisms. Here, authors employ cryogenic electron microscopy to uncover how interfacial chemistry governs magnesium deposition across diverse electrolytes.

An Ohmic contact interface engineering strategy was proposed by loading copper nano islands on indium hydroxide nanocubes, which could trigger and stabilize the polarized Cu0 -Cuδ+ active sites. Such catalyst enabled effective ammonia electrosynthesis with nitrate under ambient conditions

Transplanted older livers are prone to injury through unclear mechanisms, precluding effective treatment development. Here, the authors show that decreased FTO expression in older livers inhibits Acsl4 and Tfrc mRNA stability in an m6A-dependent manner, increasing cell death in older donor livers.

This study shows that Galectin-3 promotes wound healing by binding to and undergoing phase separation with integrin α5β1, a process disrupted by AGEs in pre-clinical models of diabetes. Topical Galectin-3 restored healing in synergy with insulin.

Solar-powered desalination is a sustainable approach to generate clean water for our society. Here, authors report lightweight, flexible, and fluidic-diode membrane-based evaporators to allow directional water transport and optimized heat localization. This Janus evaporator design enables high performance interfacial solar water evaporation, as well as hydrovoltaic applications.

Clean-up of oil spills is a global challenge because current methods are ineffective when facing highly viscous oil with low fluidity. Here the authors develop a tool for efficient and high-throughput clean-up of highly viscous oil spills.

Sorption-based atmospheric water harvesting has the capability of capturing water from air anytime and anywhere. A facile strategy to synthesize bidirectionally aligned and hierarchically structured nanocomposite could realize scalable and efficient sorption-based atmospheric water harvesting.

A strategy that depends on attenuated brassinosteroid signalling is described for the design of semi-dwarf wheat varieties with improved grain yield compared with that of green revolution varieties.

Urea is one the most-used synthetic nitrogen fertilizers that have been key to feeding a growing population. However, its production is energy intensive. Here, the authors show an electrocatalytic approach that allows for selective urea synthesis from nitrate and carbon dioxide at ambient conditions.

How tissues adapt to extreme cold is not well understood. Here, the authors discover a mechanism that promotes FOXO1-mediated cold survival gene transcription at low temperatures, with potential implications for long-term tissue storage for transplantation.

Wang and colleagues generate two protein-level mutant p53 reporters and use them to identify precancerous clones in normal tissues in vivo, characterized by increased amino acid metabolism and a transcriptomic signature that includes Ybx3.

Chromosome-level genome assemblies of 11 bamboo species comprising lineages from diploid (herbaceous) to tetraploid and hexaploid (woody) provide insights into dynamic subgenome dominance in bamboos.

IL-6 is an important cytokine in the tumour microenvironment, but its role in regulating autophagy in cancer cells is unclear. Here the authors show that IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator, BECN1, which leads to chemotherapeutic resistance.

Converting nitrate from waste sources into ammonia provides an effective method for both wastewater treatment and ammonia production. Here the authors report a scalable solution-phase synthesis of high-entropy single-atom nanocage catalysts for efficient nitrate-to-ammonia conversion.

Supercontinuum generation can be utilized for light source development. Here the authors demonstrate ultraviolet supercontinuum generation from ions due to strong field ionization and multiphoton resonance effect.

Single-atom catalysts containing Fe–N₄ active sites have been developed as effective noble-metal-free catalysts for the oxygen reduction reaction. Here the authors untangle the effects of active site density and cooperativity between neighbouring single-atom sites at well-defined distances.

Although some transition metal oxide-based electrodes exhibit high storage capacities beyond theoretical values, the underlying physicochemical mechanism remains elusive. Surface capacitance on metal nanoparticles involving spin-polarized electrons is now shown to be consistent with a space charge mechanism.

Using a chemical screening approach, Yang and colleagues identify PKC as a regulator of lysosome biogenesis, which controls the subcellular localization of TFEB and ZKSCAN3 through parallel signalling pathways and independently of mTORC1.

Solar cells based on such coaxial nanowires made from silicon have been fabricated. Under a standard one solar equivalent (1-sun) illumination a maximum power output up to 200 pW per nanowire and an apparent energy conversion efficiency of up to 3.4% is achieved. Experiments demonstrate that such silicon nanowire photovoltaic elements can serve as robust power sources in nanoelectronic circuits.

Jun Wang and colleagues report whole-genome resequencing of 17 wild and 14 cultivated soybean accessions. They characterize population structure, patterns of linkage disequilibrium and selection in soybeans.

The abnormal structural‒functional coupling patterning of progressive supranuclear palsy is related to diverse hierarchical gradients and cellular histological features.

Hydrogels are attractive for the treatment of waste water, but their mechanical properties are typically reduced when underwater. Here, a synthesis strategy is reported for a graphene oxide-coated hydrogel which can catalyze organic dye degradation in water over multiple cycles.