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Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis. Here the authors report that deficiency of Pck1 in the liver leads to nonalcoholic fatty liver disease via activation of the RhoA/PI3K/AKT pathway in a study with male mice.

Qian Ye
Yi Liu
Ni Tang
ResearchOpen Access14 Mar 2023
Nature Communications

Volume: 14, P: 1-19
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM.

Tingting Li
Xiaojian Han
Aishun Jin
ResearchOpen Access02 Nov 2021
Nature Communications

Volume: 12, P: 1-11
Investigation and mitigation of degradation mechanisms in Cu₂O photoelectrodes for CO₂ reduction to ethylene

Photoelectrodes for light-driven CO₂ reduction to fuels and chemicals often suffer drastic decreases in performance due to changes in the material under illumination. Here the authors investigate the degradation pathways that occur in Cu₂O photocathodes for ethylene synthesis and put forward strategies to mitigate them.

Guiji Liu
Fan Zheng
Francesca M. Toma
Research08 Nov 2021
Nature Energy

Volume: 6, P: 1124-1132
Development of a photoelectrochemically self-improving Si/GaN photocathode for efficient and durable H₂ production

Development of efficient yet durable photoelectrodes is of paramount importance for deployment of solar-fuel production. The photoelectrochemically self-improving behaviour of a silicon/gallium nitride photocathode highly efficient for hydrogen production is now reported.

Guosong Zeng
Tuan Anh Pham
Francesca M. Toma
Research05 Apr 2021
Nature Materials

Volume: 20, P: 1130-1135
SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC

Qingzhu Gao
Guiji Zhang
Ni Tang
Research31 Jul 2019
Cell Death & Differentiation

Volume: 27, P: 1086-1104
DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma

Guiji Zhang
Xia Tang
Keyue Ding
Research19 Feb 2020
Oncogene

Volume: 39, P: 3229-3244
Wafer-scale fabrication of solid-state nanopore array with a novel SpacerX process

Lihuan Zhao
Jiajun Wang
Xin Zhao
ResearchOpen Access25 Jun 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-11
A compact platform for the investigation of material dynamics in quasi-isentropic compression to ~ 19 GPa

Yu Lu
Kaiguo Chen
Chengwei Sun
ResearchOpen Access19 Oct 2021
Scientific Reports

Volume: 11, P: 1-12

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Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

Investigation and mitigation of degradation mechanisms in Cu₂O photoelectrodes for CO₂ reduction to ethylene

Development of a photoelectrochemically self-improving Si/GaN photocathode for efficient and durable H₂ production

SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC

DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma

Wafer-scale fabrication of solid-state nanopore array with a novel SpacerX process

A compact platform for the investigation of material dynamics in quasi-isentropic compression to ~ 19 GPa

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