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Showing 1–5 of 5 results
Advanced filters: Author: Guillaume Assié Clear advanced filters

  • Adrenocortical carcinomas (ACC) are aggressive and often resistant to therapy. Here, the authors provide a single-nucleus transcriptomic atlas of ACCs and normal adrenal glands, finding ecotypes in steroid and microenvironment cells that are associated with clinical outcomes.

    • Anne Jouinot
    • Yoann Martin
    • Guillaume Assié
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • This Review describes the progress that has been made towards classification of adrenocortical tumours to date based on key genomic approaches. In addition, the potential for the development and use of various molecular tools to personalize the management of patients with adrenocortical tumours is discussed.

    • Guillaume Assié
    • Anne Jouinot
    • Jérôme Bertherat
    Reviews
    Nature Reviews Endocrinology
    Volume: 10, P: 215-228

  • Jérôme Bertherat, Aurélien de Reyniès and colleagues perform integrated genomic analyses of adrenocortical carcinomas. They discover recurrent alterations in several new driver genes, including ZNRF3, DAXX, TERT and MED12, and identify two distinct molecular subgroups with opposite clinical outcomes.

    • Guillaume Assié
    • Eric Letouzé
    • Jérôme Bertherat
    Research
    Nature Genetics
    Volume: 46, P: 607-612

  • Cancer immunotherapies utilize the immune system to attack tumour cells but steroid hormones have immunosuppressive effects that can reduce immunotherapy efficacy. This Review discusses the role of steroid hormones, both endogenous and exogenous, on tumour-associated immune cells and cancer immunotherapies.

    • Paul Schwarzlmueller
    • Alexandra Triebig
    • Matthias Kroiss
    Reviews
    Nature Reviews Endocrinology
    Volume: 21, P: 331-343