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Nature Structural & Molecular Biology (1)

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A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance

Lu et al. report a D compartment in Caenorhabditis elegans germ granules, formed by DEAD-box RNA helicase DDX-19 and nuclear pore proteins. This compartment anchors granules to nuclear pores, ensuring compartmentalization, RNA surveillance and germline immortality.

Pu Lu
Boyuan Deng
Gang Wan
Research13 Mar 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1241-1254

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A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance

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