Nature Search

A transcriptome based molecular classification scheme for cholangiocarcinoma and subtype-derived prognostic biomarker

Cholangiocarcinoma can arise anywhere within the biliary tree and is classified by anatomical locations. Here, the authors utilised RNAseq from 438 CCA patients and propose a molecular classification system independent of location.

Zhongqi Fan
Xinchen Zou
Guoyue Lv
ResearchOpen Access11 Jan 2024
Nature Communications

Volume: 15, P: 1-14
Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

Wenying Yang
Dalong Zhu
Li Chen
ResearchOpen Access12 May 2022
Nature Medicine

Volume: 28, P: 974-981
Microbiota-derived H₂S induces c-kit⁺ cDC1 autophagic cell death and liver inflammation in metabolic dysfunction-associated steatohepatitis

The immune regulatory mechanism for metabolic dysfunction-associated steatohepatitis (MASH) remains elusive. Here, the authors identify a c-kit⁺ cDC1 subset, which can be depleted by Desulfovibrio_sp.-induced H₂S via autophagic cell death and contributing to uncontrolled inflammation for MASH progression.

Yuxiang Song
Na Li
Xinwei Li
ResearchOpen Access05 Mar 2025
Nature Communications

Volume: 16, P: 1-19
Dorzagliatin in drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial

The SEED study is a phase 3 clinical trial demonstrating a beneficial effect on glycemic control of dorzagliatin, a glucokinase activator, in drug-naive patients with newly diagnosed type 2 diabetes.

Dalong Zhu
Xiaoying Li
Li Chen
Research12 May 2022
Nature Medicine

Volume: 28, P: 965-973
The RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function

Wheat E3 ubiquitin ligase TaPIR1-mediated ubiquitination and degradation of an atypical transcription factor TaHRP1 alters PhANGs expression to disrupt chloroplast function and ROS accumulation, increasing plant susceptibility to wheat stripe rust.

Rongrong Zhang
Yu Wu
Qiang Xu
ResearchOpen Access12 Aug 2024
Nature Communications

Volume: 15, P: 1-17
Edge-guided multi-scale adaptive feature fusion network for liver tumor segmentation

Tiange Zhang
Yuefeng Liu
Hongyu Shen
ResearchOpen Access17 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation

Huiting Deng
Hailin Liu
Yahui Ding
ResearchOpen Access30 Mar 2023
Oncogenesis

Volume: 12, P: 1-12
Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis

Feiye Zhou
Qianqian Liu
Libin Zhou
ResearchOpen Access11 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-12
Ionic liquids modified graphene oxide composites: a high efficient adsorbent for phthalates from aqueous solution

Xinguang Zhou
Yinglu Zhang
Guoyue Shi
ResearchOpen Access02 Dec 2016
Scientific Reports

Volume: 6, P: 1-10
The Regulatory Effect of UL-16 Binding Protein-3 Expression on the Cytotoxicity of NK Cells in Cancer Patients

Xiao Mou
Yuepeng Zhou
Chaoming Mao
ResearchOpen Access20 Aug 2014
Scientific Reports

Volume: 4, P: 1-8
RNA architecture of porcine deltacoronavirus genome inside virions detected by vRIC-seq

Ju Sun
Zhiyuan Huang
Dengguo Wei
ResearchOpen Access14 Oct 2024
Scientific Data

Volume: 11, P: 1-11

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