Nature Search

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficacy of TREM2 agonism informing current clinical efforts.

Astrid F. Feiten
Kilian Dahm
Christian Haass
ResearchOpen Access24 Jan 2026
Nature Communications

P: 1-22
Optimal murine CD4⁺ T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing

Lipid nanoparticle based mRNA vaccines are known to induce robust CD4 + T cell responses. Here the authors establish a role of endogenously derived antigen processing in the optimal priming of CD4 + T cell responses to mRNA lipid nanoparticle vaccines.

Julia E. Rood
Suh Kyung Yoon
Laurence C. Eisenlohr
ResearchOpen Access16 Jan 2026
Nature Communications

P: 1-11
Activation of the β1 isozyme of phospholipase C by α subunits of the G_q class of G proteins

Stephen J. Taylor
Ho Zoon Chae
John H. Exton
Research11 Apr 1991
Nature

Volume: 350, P: 516-518
DeltaC and DeltaD ligands play different roles in the segmentation clock dynamics

The vertebrate segmentation clock relies on a Notch signaling and Hes/her oscillations to coordinate the periodic formation of somites. Here they examine how different DeltaC/D hetero- and homodimers impact the expression of her1 and her7 and uncover a feedforward loop that perpetuates clock activity.

Eslim Esra Alpay
Oriana Q. H. Zinani
Ertuğrul M. Özbudak
ResearchOpen Access11 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Spatial transcriptomics of the developing mouse brain immune landscape reveals effects of maternal immune activation and microbiome depletion

Kukreja, Jeon et al. leverage spatial transcriptomics to map immune gene expression in the developing mouse brain, identifying key sex-specific changes in the context of maternal gut−immune perturbations.

Bharti Kukreja
Shin Jeon
Brian T. Kalish
Research06 Jan 2026
Nature Neuroscience

P: 1-14
Crystal structure of the active site of ribulose-bisphosphate carboxylase

Inger Andersson
Stefan Knight
George H. Lorimer
Research19 Jan 1989
Nature

Volume: 337, P: 229-234
Niche appropriation by Drosophila intestinal stem cell tumours

Patel et al. report that Drosophila intestinal stem cell tumours are generated by stress- and EGFR-signalling, followed by extrusion of neighbouring enterocytes, enterocytic cytokine expression and paracrine signalling for tumour growth.

Parthive H. Patel
Devanjali Dutta
Bruce A. Edgar
Research03 Aug 2015
Nature Cell Biology

Volume: 17, P: 1182-1192
Retraction Note: Claudin-1 induces epithelial–mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells

Y. Suh
C-H Yoon
S-J Lee
Amendments and Corrections09 Jan 2026
Oncogene

Volume: 45, P: 591
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells

An amphiphilic mimotope vaccine can be used in tandem with Food and Drug Administration (FDA)-approved CD19 CAR-T cell products.

Tomasz M. Grzywa
Alexandra Neeser
Darrell J. Irvine
ResearchOpen Access25 Aug 2025
Nature Biomedical Engineering

P: 1-21
Engineering N-glycosylation mutations in IL-12 enhances sustained cytotoxic T lymphocyte responses for DNA immunization

Sang J. Ha
Jun Chang
Young C. Sung
Research01 Apr 2002
Nature Biotechnology

Volume: 20, P: 381-386
Ultrafast space-time optical merons in momentum-energy space

Recently, the increased capabilities in generating pulsed optical fields that are rigidly transported in linear media without diffraction or dispersion has opened the path to realisation of 3D optical skyrmionic structures. Here, the authors demonstrate 3D-localized optical merons by imprinting polarization textures onto the momentum-energy space of ultrafast light pulses.

Murat Yessenov
Ahmed H. Dorrah
Ayman F. Abouraddy
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-10
Designing a magnesium alloy with high strength and high formability

Despite being the lightest structural alloys, obtaining magnesium alloys with both high strength and high formability remains a challenge. Here, the authors use precipitation and elemental segregation to design a magnesium alloy with high strength and high formability.

T. T. T. Trang
J. H. Zhang
N. J. Kim
ResearchOpen Access28 Jun 2018
Nature Communications

Volume: 9, P: 1-6
Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase

Clarissa Gerhäuser
Woongchon Mar
John M. Pezzuto
Research01 Mar 1995
Nature Medicine

Volume: 1, P: 260-266
Arrays of Lucius microprisms for directional allocation of light and autostereoscopic three-dimensional displays

Autostereoscopic three-dimensional displays allow the perception of depth, by presenting offset images to the left and right eye, without the need for specialized glasses. Yoonet al propose a Luciusmicroprism array to control the directionality and intensity of light in three-dimensional displays.

Hyunsik Yoon
Sang-Guen Oh
Hong H. Lee
Research30 Aug 2011
Nature Communications

Volume: 2, P: 1-5
Discovery and population genomics of structural variation in a songbird genus

Structural genomic variation can fuel evolution. Here, authors present genome data from seven Corvus species and unearth structural variants that vary between incipient crow species in Europe, with implications for premating isolation involving plumage patterning.

Matthias H. Weissensteiner
Ignas Bunikis
Jochen B. W. Wolf
ResearchOpen Access07 Jul 2020
Nature Communications

Volume: 11, P: 1-11
In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

Leber congenital amaurosis is caused by mutations in RPE65 and leads to retinal degeneration in children. Here, the authors show that in vivo base editing can prolong the survival of cone photoreceptors and rescue their function in a mouse model of the disease.

Elliot H. Choi
Susie Suh
Krzysztof Palczewski
ResearchOpen Access05 Apr 2022
Nature Communications

Volume: 13, P: 1-14
Revealing the location and dynamics of a concealed binding site in the dopamine transporter

The number of ligand binding sites in the dopamine transporter is enigmatic due to conflicting data from structures and molecular pharmacology. Here, force spectra reveal the position and dynamics of a previously invisible transient site.

Rong Zhu
Walter Sandtner
Peter Hinterdorfer
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-12
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

Scott G. Clark
Michael J. Stern
H. Robert Horvritz
Research26 Mar 1992
Nature

Volume: 356, P: 340-344
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease

Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

Sophia M. Shi
Ryan J. Suh
Tony Wyss-Coray
ResearchOpen Access26 Feb 2025
Nature

Volume: 639, P: 985-994
GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism

R. H. Weisbart
A. Kacena
D. W. Golde
Research14 Apr 1988
Nature

Volume: 332, P: 647-648
Free-standing bilayer metasurfaces in the visible

Compound meta-optics enable advanced functionality yet suffer from Fresnel losses and low mode confinement. Here, using an innovative two-step lithography process, the authors introduce bilayer metasurfaces made of freestanding titania meta-atoms, enabling geometric phase control on linearly polarized light with 80% efficiency in the visible.

Ahmed H. Dorrah
Joon-Suh Park
Federico Capasso
ResearchOpen Access01 Apr 2025
Nature Communications

Volume: 16, P: 1-10
Endotoxin-induced uveitis in rats as a model for human disease

J. T. Rosenbaum
H. O. McDevitt
P. R. Egbert
Research07 Aug 1980
Nature

Volume: 286, P: 611-613
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this disorder. The findings highlight distinct disease mechanisms, emphasizing the roles of immunity and the notch signaling pathway.

Cyril Pottier
Fahri Küçükali
Rosa Rademakers
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-19
An inflammatory biomarker signature of response to CAR-T cell therapy in non-Hodgkin lymphoma

A preinfusion circulatory inflammation biomarker-based signature predicts the likelihood of treatment failure in patients with non-Hodgkin lymphoma who were treated with CAR-T cell therapy, with an inflammatory cluster assignment being prognostic of clinical response and survival outcomes.

Sandeep S. Raj
Teng Fei
Roni Shouval
ResearchOpen Access01 Apr 2025
Nature Medicine

Volume: 31, P: 1183-1194
Familial Hypomagnesemia—A Follow-Up Examination of Three Patients After 9 to 12 Years of Treatment

Johan H Strømme
Jon Steen-johnsen
Petter Brandtzaeg
Research01 Aug 1981
Pediatric Research

Volume: 15, P: 1134-1139
Small Molecule Antagonists of NAADP-Induced Ca²⁺ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Bo Zhang
Joanna M Watt
Barry V. L. Potter
ResearchOpen Access13 Nov 2018
Scientific Reports

Volume: 8, P: 1-17
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

Subretinal viral delivery, in mice, of an adenine base editor and a single-guide RNA targeting a nonsense mutation in the Rpe65 gene restores near-normal levels of retinal and visual functions.

Susie Suh
Elliot H. Choi
Krzysztof Palczewski
Research19 Oct 2020
Nature Biomedical Engineering

Volume: 5, P: 169-178
Inactivation of Thrombin by Normal Human Urine

H. A. GAERTNER
J. LISIEWICZ
E. SZIRMAI
Research12 Jan 1963
Nature

Volume: 197, P: 188-189
Unusual Waveguide Characteristics associated with the Apparent Negative Permeability obtainable in Ferrites

G. H. B. THOMPSON
Research25 Jun 1955
Nature

Volume: 175, P: 1135-1136
The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome

Markus Rohrwild
Günter Pfeifer
Alfred L. Goldberg
Research01 Feb 1997
Nature Structural Biology

Volume: 4, P: 133-139
Introducing the University of California, Irvine Corneal Cystine Crystal Score: A Novel Tool for Assessing Corneal Crystal Deposition in Cystinosis Patients

Kimia Rezaei
Kourosh Shahraki
Donny W. Suh
ResearchOpen Access16 Oct 2025
Scientific Reports

Volume: 15, P: 1-7
Hippo–YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

The transcriptional coregulators YAP/TAZ are shown to directly control leptin gene transcription, thereby uncoupling adipose tissue mass from leptin levels.

Sungwoo Choi
Ju-Gyeong Kang
Jae Myoung Suh
ResearchOpen Access29 May 2024
Nature Metabolism

Volume: 6, P: 847-860
Genomic insights into rapid speciation within the world’s largest tree genus Syzygium

The relative importance of the mechanisms underlying species radiation remains unclear. Here, the authors combine reference genome assembly and population genetics analyses to show that neutral forces have contributed to the radiation of the most species-rich tree genus Syzygium.

Yee Wen Low
Sitaram Rajaraman
Victor A. Albert
ResearchOpen Access12 Sept 2022
Nature Communications

Volume: 13, P: 1-15
Maintenance of CD8+T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease

Juyang Kim
Hye J Kim
Byungsuk Kwon
ResearchOpen Access01 Oct 2006
Experimental & Molecular Medicine

Volume: 38, P: 494-501
Genetic retrieval of viral genome sequences from herpes simplex virus transformed cells

M. Park
D. M. Lonsdale
J. C. M. Macnab
Research05 Jun 1980
Nature

Volume: 285, P: 412-415
Impaired wound healing in mice with a disrupted plasminogen gene

John Rømer
Thomas H. Bugge
Keld Danø
Research01 Mar 1996
Nature Medicine

Volume: 2, P: 287-292
Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions

Hiroyuki Koyama
Hideo Kagaya
Tetsuro Miyata
ResearchOpen Access18 Oct 2010
Nature Precedings

P: 1
Vitamin B₁₂ as a Growth Factor for Soil Bacteria

A. G. LOCHHEAD
R. H. THEXTON
Research23 Jun 1951
Nature

Volume: 167, P: 1034
Effect of Different Dietary Fats on the Fæcal End-Products of Cholesterol Metabolism

H. GORDON
B. LEWIS
J. F. BROCK
Research02 Nov 1957
Nature

Volume: 180, P: 923-924
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Science at Oxford

CHARLES H. WADE
Research15 Mar 1877
Nature

Volume: 15, P: 430
Discovery of a double radio source associated with Cygnus X-3

R. G. Strom
J. van Paradijs
M. van der Klis
Research19 Jan 1989
Nature

Volume: 337, P: 234-236
Observation of minimal and maximal speed limits for few and many-body states

Quantum speed limits are fundamental constraints on the speed of quantum state evolution. Here, the authors observe the known maximal quantum speed limits for few and many-body states on a superconducting quantum processor and identify the minimal quantum speed limits, which are less common than maximal ones.

Zitian Zhu
Lei Gao
Rubem Mondaini
ResearchOpen Access01 Feb 2025
Nature Communications

Volume: 16, P: 1-9
Inhibition of Delta-induced Notch signaling using fucose analogs

Protein O-fucosyltransferase 1 (Pofut1) regulates Notch activity by adding O-fucose residues to its extracellular domain. Fucose analogs were identified that inhibited Delta-mediated Notch binding and activation but spared Jagged1-mediated signaling.

Michael Schneider
Vivek Kumar
Robert S Haltiwanger
Research27 Nov 2017
Nature Chemical Biology

Volume: 14, P: 65-71
Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations

The safety and efficacy of ribonucleoproteins for genome editing can be enhanced by formulations of lipid nanoparticles optimized for enhanced stability, delivery efficiency and editing potency of the protein complexes.

Rafał Hołubowicz
Samuel W. Du
Krzysztof Palczewski
ResearchOpen Access28 Nov 2024
Nature Biomedical Engineering

Volume: 9, P: 57-78
Distinct activity-gated pathways mediate attraction and aversion to CO₂ in Drosophila

Drosophila melanogaster are attracted to CO₂ when in an active, foraging state but experience aversion to CO₂ at low-activity levels, whereas they are attracted to ethanol in all behavioural states.

Floris van Breugel
Ainul Huda
Michael H. Dickinson
Research21 Nov 2018
Nature

Volume: 564, P: 420-424
Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice

D. Bucchini
C-A. Reynaud
J-C. Weill
Research26 Mar 1987
Nature

Volume: 326, P: 409-411
ATP-dependent inositide phosphorylation required for Ca²⁺-activated secretion

Jesse C. Hay
Phillip L Fisette
Thomas F. J. Martin
Research09 Mar 1995
Nature

Volume: 374, P: 173-177
Representation of the secondary and tertiary structure of group I introns

Thomas R. Cech
Simon H. Damberger
Robin R. Gutell
Research01 May 1994
Nature Structural Biology

Volume: 1, P: 273-280
Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

Intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. Here the authors show that VEGF-C expression in specialized IntSCs is regulated by YAP/TAZ, and VEGF-C is responsible for maintaining lacteal integrity, thus influencing dietary fat drainage into lacteals.

Seon Pyo Hong
Myung Jin Yang
Gou Young Koh
ResearchOpen Access14 Aug 2020
Nature Communications

Volume: 11, P: 1-16

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