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In the randomized phase 3 AMPLITUDE trial, patients with HRR-deficient mCSPC experienced longer progression-free survival when they were treated with niraparib and AAP compared to placebo and AAP.

In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

Near infrared energy remains untapped toward the maneuvering of entire solar spectrum harvesting for fulfilling nuts and bolts of solar hydrogen production. Here, the authors report the use of Au@Cu₇S₄ yolk@shell nanocrystals for hydrogen production from untapped near infrared energy.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Here, the authors perform plaque reduction neutralization (PRNT) assays quantitating SARS-CoV-2 specific neutralizing antibodies from 195 patients in different disease states and find that patients with severe disease exhibit higher peaks of neutralizing antibody titres than patients with mild or asymptomatic infections and that serum neutralizing antibody persists for over 6 months in most people.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

The superoxide radical anion is a fundamental reactive oxygen species, with important functions in plant growth, development and stress responses. A search for ‘superoxide anion’ and ‘plant’ in PubMed retrieved 3,327 publications since the year 2000, with 87 of these publications in 2025 through June. Unfortunately, despite the biological ubiquity of the superoxide anion, inconsistent and chemically inaccurate notation widely persists in the plant biological literature. This Comment clarifies the correct notation for the superoxide anion (O ₂ ^•− ), highlights widespread errors and urges standardization to prevent scientific ambiguity.

Installation of multiple C–O bonds by concurrent oxygenation of contiguous C–H bonds in a selective fashion is highly desirable, and this is achieved by repeated operation of a potent oxidative catalyst via electrophotocatalysis.

TDP-43 proteinopathies are characterized by TDP-43 aggregates but the relationship of these aggregates to the pathogenesis is still not well defined. Here, the authors show that the recombinant full-length human TDP-43 forms oligomers that are neurotoxic, can promote the formation of A-beta amyloid oligomers in vitroand can be detected in postmortem brain of patients.

Pangenome analyses of 133 wild accessions of the model bryophyte Marchantia polymorpha identify adaptive features and provide insights into the mechanisms of plant adaptation to the terrestrial environment.

The development of antimalarials against the human liver and asexual blood stages is one of the top public health challenges. Here, the authors report a single-step biochemical assay for the characterization of prolyl-tRNA synthetase inhibitors, and develop high-affinity inhibitors for the enzyme, including elusive triple-site ligands.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Human and mouse astrocytes express the protocadherin PcdhγC3, which promotes self-recognition of individual astrocytes, thereby contributing to normal astrocyte and brain development.

The formation of 2D perovskites in inorganic perovskite solar cells is hindered by the strong binding affinity of caesium ions. Liu et al. engineer the functional groups of a large organic cation to facilitate its exchange with caesium ions and form a stable 2D perovskite.

There are very few methods for the organocatalytic aziridination of unactivated olefins. Here the authors report a simple ketone catalyst for the transfer of nitrogen to isolated carbon–carbon double bonds, with good substrate scope and in high yields.

An integrated dataset combining genetics, epigenomics, transcriptomics, proteomics and metabolomics from 1,342 people living with HIV illuminates molecular pathways driving immune responses and comorbidities in this population.

A biodegradable probe made of dextran and a urea-based targeting ligand for prostate-specific membrane antigen enables targeted magnetic resonance imaging of tumours expressing the receptor in a xenograft mouse model of prostate cancer.

Spin ices are magnetic materials in which excitations equivalent to monopoles can occur. Using high-pressure techniques, Zhouet al. synthesize a new member of the spin ice family, Dy₂Ge₂O₇, in which monopoles exist at higher densities, and can stabilize as dimers.

The nature of unconventional charge density wave in kagome metals is currently under intense debate. Here the authors report the coexistence of the 2 × 2 × 1 charge density wave in the kagome sublattice and the Sb 5p-electron assisted 2 × 2 × 2 charge density waves in CsV₃Sb₅.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

Despite the development of inhibitors targeting active GTP-bound (ON) KRAS(G12C) for the treatment of KRAS G12C-driven non-small cell lung cancer (NSCLC), resistance remains an issue. Here, the authors show that despite inhibition of KRAS G12C ON, there is residual mTOR activity driving resistance, which was successfully targeted by combining with a selective mTOR inhibitor.

Abrupt millennial-scale climate variability, known as Dansgaard-Oeschger (D-O) events, characterized the last glacial. Stalagmite data from northern Türkiye show D-O events for the penultimate glacial period, though they were less frequent.

A visible stimulated Raman scattering microscope with extensive pulse chirping in combination with a deep-learning-based denoiser and Fourier reweighting leads to highly sensitive, label-free imaging of cell metabolism at the nanoscale.

Genetic background, plasma metabolome and dietary data from 4,215 women and 1,490 men reveal 57 metabolites whose associations with dementia risk vary by APOE4 genotype and other risk variants.

Magnetic losses are a major source of inefficiency in power electronics. Minimizing these losses requires soft magnetic materials with high saturation magnetization, low coercivity, and low core loss at high frequency. Here, Gautam et al present an approach combining nanostructure engineering with high frequency domain structure control, reducing core losses by 55%.

The process of thin sheet crumpling is characterized by high complexity due to an infinite number of possible configurations. Andrejevic et al. show that ordered behavior can emerge in crumpled sheets, and uncover the correspondence between crumpling and fragmentation processes.

The understanding of the reemergence of pressure induced superconductivity in alkali-metal intercalated FeSe is hampered by sample complexities. Here, Sun et al. report the electronic properties of (Li_1–xFe _x )OHFe_1–ySe single crystal not only in the reemerged superconducting state but also in the normal state.

An exploration of previously undescribed variants from the long tail of the CRISPR–Cas distribution.

Chen et al. use UK Biobank data to reveal a dietary pattern associated with a lower risk of dementia, and validate this in additional cohorts.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Although ubiquitin ligases are known to control clock protein degradation, their other roles in clock neurons are unclear. Here the authors report that UBR4 promotes export of neuropeptides from the Golgi for axonal trafficking, which is important for circadian clock synchrony in mice and flies.