The authors test whether experience-dependent neocortical modifications need Ube3a, an ubiquitin ligase implicated in autism and Angelman syndrome, using a mouse model of Angelman syndrome. They find that experience-dependent maturation of excitatory circuits in the visual cortex is impaired in these mice and that there are deficits in plasticity. This loss of plasticity was reversible with visual deprivation.
- Koji Yashiro
- Thorfinn T Riday
- Benjamin D Philpot
