The endoplasmic reticulum (ER) is the major site for lipid synthesis, yet the role of lipids in ER morphogenesis remains elusive. Here, Adachi et al. identify the ER-resident enzyme AGPAT2, which binds to DRP1 and supplies phosphatidic acid to regulate ER morphology. The association of DRP1 with phosphatidic acid subsequently promotes ER tubulation.
- Yoshihiro Adachi
- Mauricio Torres
- Hiromi Sesaki
