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Showing 1–50 of 66 results

Advanced filters: Author: Hajime Inoue Clear advanced filters

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Phase-separated structure and optical properties of simultaneously polymerized polymethacrylate/polyurethane blends

In this study, a polymer blend with a salami structure with dimensions of several tens of microns was obtained by simultaneously polymerizing polymethacrylate and polyurethane. The methacrylate component of the polymer blend was co-polymerized with hydroxyethyl methacrylate (HEMA), which contains a hydroxyl group. The HEMA copolymerization increased the compatibility between the polyurethane and polymethacrylate regions. Consequently, the hard areas within the spherical domains decreased in size, accompanied by a decrease in the differences in composition and refractive index between regions.

Shiho Kuwashiro
Kosaku Tao
Masashi Nakamura
ResearchOpen Access18 Dec 2025
Polymer Journal

P: 1-9
Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor β locus

Kazuhiro Tsukamoto
Satoshi Inoue
M. Emi
Research01 Feb 1998
Journal of Human Genetics

Volume: 43, P: 73-74
Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging

Here, the authors identify the microbiota-derived corisin as a driver of diabetic kidney fibrosis via cellular aging and show that targeting corisin with a monoclonal antibody alleviates disease in mice, suggesting a potential therapeutic avenue.

Taro Yasuma
Hajime Fujimoto
Esteban C. Gabazza
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-29
Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene

Hiroshi Ichinose
Tamae Ohye
Toshiharu Nagatsu
Research01 Nov 1994
Nature Genetics

Volume: 8, P: 236-242
Association of radial bone mineral density with CA repeat polymorphism at the interleukin 6 locus in postmenoposal Japanese women

Kazuhiro Tsukamoto
Hideo Yoshida
M. Emi
Research01 May 1999
Journal of Human Genetics

Volume: 44, P: 148-151
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Additional Arctic observations improve weather and sea-ice forecasts for the Northern Sea Route

Jun Inoue
Akira Yamazaki
Hajime Yamaguchi
ResearchOpen Access20 Nov 2015
Scientific Reports

Volume: 5, P: 1-8
Erratum: Rational design of a high-affinity, fast, red calcium indicator R-CaMP2

Masatoshi Inoue
Atsuya Takeuchi
Haruhiko Bito
Amendments and Corrections28 Aug 2015
Nature Methods

Volume: 12, P: 893
A survey of wheelchair use by paraplegic individuals in Japan. Part 2: Prevalence of pressure sores

Tadashi Sumiya
Kenji Kawamura
Hajime Ogata
Research01 Sept 1997
Spinal Cord

Volume: 35, P: 595-598
Comparison of Packing Modes of Poly(thiophene)s and Poly(thiazole)s

Takakazu Yamamoto
Bang-Lin Lee
Shintaro Sasaki
Research01 Oct 1998
Polymer Journal

Volume: 30, P: 853-856
Spatial community shift from hard to soft corals in acidified water

Research combining the analysis of coral distribution in volcanically acidified waters with laboratory culture experiments indicates that reef communities may shift from reef-building hard corals to non-reef-building soft corals under CO₂ partial pressure ( $p_{{CO}_{2}}$ ) levels of 550–970 μatm that are predicted to occur by the end of this century.

Shihori Inoue
Hajime Kayanne
Haruko Kurihara
Research24 Mar 2013
Nature Climate Change

Volume: 3, P: 683-687
Domain-adaptive semi-supervised learning for efficient rare pathological lesion detection with minimal annotation

Isao Matsui
Ayumi Matsumoto
Yoshitaka Isaka
ResearchOpen Access23 Nov 2025
npj Digital Medicine

Volume: 8, P: 1-16
Evaluation of offset of conjunctival hyperemia induced by a Rho-kinase inhibitor; 0.4% Ripasudil ophthalmic solution clinical trial

Emi Sakamoto
Waka Ishida
Atsuki Fukushima
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-8
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A survey of wheelchair use by paraplegic individuals in Japan. Part 1: Characteristics of wheelchair cushions

Tadashi Sumiya
Kenji Kawamura
Hajime Ogata
Research01 Sept 1997
Spinal Cord

Volume: 35, P: 590-594
Effect of Enzymic Hydrolysis of the Scissile Bond on the Secondary Structure of a Dimeric Globular Protein

Tomoko Komiyama
Takayasu Mori
Makoto Miwa
Research01 Feb 1986
Polymer Journal

Volume: 18, P: 103-109
Synthesis and Biodegradability of Copolymers of Ethylene Carbonate with Lactones

Hiroyuki Shirahama
Akinori Kanetani
Hajime Yasuda
Research01 Mar 2000
Polymer Journal

Volume: 32, P: 280-286
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Anthropogenic Anoxic History of the Tuvalu Atoll Recorded as Annual Black Bands in Coral

Nobuko Nakamura
Hajime Kayanne
Hiroya Yamano
ResearchOpen Access30 Apr 2020
Scientific Reports

Volume: 10, P: 1-9
Efficacy of combined transbronchial lung cryobiopsy and conventional forceps biopsy for lung malignancies: a prospective cohort study

Kohei Kinoshita
Kei Morikawa
Masamichi Mineshita
ResearchOpen Access01 Feb 2023
Scientific Reports

Volume: 13, P: 1-8
A repeat unit of Vibrio diarrheal T3S effector subverts cytoskeletal actin homeostasis via binding to interstrand region of actin filaments

Mitsuhiro Nishimura
Takashi Fujii
Tetsuya Iida
ResearchOpen Access03 Jun 2015
Scientific Reports

Volume: 5, P: 1-8
Dual enhancement of electroluminescence efficiency and operational stability by rapid upconversion of triplet excitons in OLEDs

Taro Furukawa
Hajime Nakanotani
Chihaya Adachi
ResearchOpen Access12 Feb 2015
Scientific Reports

Volume: 5, P: 1-8
Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma

Tomohiro Yamaki
Yusuke Suenaga
Akira Nakagawara
ResearchOpen Access29 Jan 2013
Scientific Reports

Volume: 3, P: 1-7
Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis

Here, the authors show that treatment with a monoclonal neutralizing antibody against the lung microbiota-derived proapoptotic peptide corisin ameliorates acute exacerbation of pulmonary fibrosis and severity of endotoxin-induced acute lung injury in mice.

Corina N. D’Alessandro-Gabazza
Taro Yasuma
Esteban C. Gabazza
ResearchOpen Access23 Mar 2022
Nature Communications

Volume: 13, P: 1-23
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

The microbiota of centenarians (aged 100 years and older) comprise gut microorganisms that are capable of generating unique secondary bile acids, including isoallolithocholic acid, a bile acid with potent antimicrobial effects against Gram-positive—but not Gram-negative—multidrug-resistant pathogens.

Yuko Sato
Koji Atarashi
Kenya Honda
Research29 Jul 2021
Nature

Volume: 599, P: 458-464
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell carcinoma that renders it sensitive to glycolysis inhibition.

Justin Goodwin
Michael L. Neugent
Jung-whan Kim
ResearchOpen Access26 May 2017
Nature Communications

Volume: 8, P: 1-16
Mechanism behind Augmentation in Baroreflex Sensitivity after Acute Exercise in Spontaneously Hypertensive Rats

Naoyoshi Minami
Nobuyoshi Mori
Masahiro Kohzuki
Research01 Feb 2006
Hypertension Research

Volume: 29, P: 117-122
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen

The potential of extracellular vesicles (EVs) as cancer biomarkers is substantial. Here, Yoshioka et al. describe a sensitive technique to analyse EVs directly from blood samples of patients with colorectal cancer, highlighting a liquid biopsy technique with cancer-detection possibilities.

Yusuke Yoshioka
Nobuyoshi Kosaka
Takahiro Ochiya
ResearchOpen Access07 Apr 2014
Nature Communications

Volume: 5, P: 1-8
Rational design of a high-affinity, fast, red calcium indicator R-CaMP2

An improved genetically encoded red calcium sensor enables the monitoring of neuronal activity in cell culture and in vivo. R-CaMP2 has fast kinetics and a high affinity to calcium and can follow action potentials up to 40 Hz.

Masatoshi Inoue
Atsuya Takeuchi
Haruhiko Bito
Research24 Nov 2014
Nature Methods

Volume: 12, P: 64-70
TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

A G protein–coupled receptor (GPCR) signaling assay based on ectodomain shedding of a membrane-bound proform of alkaline phosphatase-tagged TGFα provides a platform for studying poorly characterized Gα_12/13-coupled GPCRs. The assay allowed identification of three orphan GPCRs as Gα_12/13-coupled lysophosphatidylserine receptors.

Asuka Inoue
Jun Ishiguro
Junken Aoki
Research16 Sept 2012
Nature Methods

Volume: 9, P: 1021-1029
Syntheses and Refractive-Indices Properties of Novel Octa-Arms Star-Shaped Polysulfides Radiating from p-t-Butylcalix[8]arene Core

Hiroto Kudo
Hajime Inoue
Tetsuo Anada
Reviews15 Feb 2006
Polymer Journal

Volume: 38, P: 289-297
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites

Yu Takata
Hiroshi Nakagawa
Masahiko Takada
ResearchOpen Access18 Feb 2021
Scientific Reports

Volume: 11, P: 1-14
Effect of farnesol on mevalonate pathway of Staphylococcus aureus

Mizuho Kaneko
Naoko Togashi
Yoshihiro Inoue
Research20 Jul 2011
The Journal of Antibiotics

Volume: 64, P: 547-549
Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets

Miki Ohira
Aiko Morohashi
Akira Nakagawara
Research21 Aug 2003
Oncogene

Volume: 22, P: 5525-5536
Analysis of mitochondrial function in human induced pluripotent stem cells from patients with mitochondrial diabetes due to the A3243G mutation

Masaki Matsubara
Hajime Kanda
Kazuwa Nakao
ResearchOpen Access17 Jan 2018
Scientific Reports

Volume: 8, P: 1-9
Author Correction: Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors

Fumine Tanaka
Maki Umino
Hajime Sakuma
Amendments and CorrectionsOpen Access28 Jul 2022
Scientific Reports

Volume: 12, P: 1-2
Uncontrolled asthma: a retrospective cohort study in Japanese patients newly prescribed with medium-/high-dose ICS/LABA

Hiromasa Inoue
Ki Lee Milligan
Masakazu Ichinose
ResearchOpen Access02 Mar 2021
npj Primary Care Respiratory Medicine

Volume: 31, P: 1-10
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
SYT, a partner of SYT-SSX oncoprotein in synovial sarcomas, interacts with mSin3A, a component of histone deacetylase complex

Tatsuo Ito
Mamoru Ouchida
Kenji Shimizu
Research04 Oct 2004
Laboratory Investigation

Volume: 84, P: 1484-1490
A genome-wide association study of third molar agenesis in Japanese and Korean populations

Shugo Haga
Hirofumi Nakaoka
Ituro Inoue
Research31 Oct 2013
Journal of Human Genetics

Volume: 58, P: 799-803
Predominant methyl radical initiation preceded by β-scission of alkoxy radicals in allyl polymerization with organic peroxide initiators at elevated temperatures

Allyl benzoate (ABz) was polymerized using dicumyl peroxide (DCPO) at 130 °C; almost no direct contribution of cumyloxy radical to initiation reaction was observed. This was extended to other organic peroxide initiators; it was confirmed that the initiation by methyl radical generated by β-scission of alkoxy radicals occurred predominantly in allyl polymerization at elevated temperatures.

Satoshi Inoue
Takeo Kumagai
Michirou Shibano
Research04 Aug 2010
Polymer Journal

Volume: 42, P: 716-721

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