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Showing 1–9 of 9 results
Advanced filters: Author: Hajin Kim Clear advanced filters

  • Theoretical studies suggest that homologous DNA duplexes can preferentially associate with one another in the absence of proteins. Here, the authors show that GC-rich DNA with methylated cytosine and AT-rich DNA duplexes associate more strongly than GC-rich duplexes regardless of the sequence homology.

    • Jejoong Yoo
    • Hajin Kim
    • Taekjip Ha
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-7

  • Sequence recognition through base pairing is essential for DNA repair and gene regulation, but the basic rules underlying this process have been unclear. Data from single-molecule fluorescence studies, used to visualize annealing and melting reactions of two untethered strands containing a single mismatch, suggest that seven contiguous base pairs are needed for rapid annealing of DNA and RNA.

    • Ibrahim I Cisse
    • Hajin Kim
    • Taekjip Ha
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 623-627

  • Ribosomes assemble through the hierarchical addition of proteins to a ribosomal RNA scaffold. Here the authors use three-color single-molecule FRET to show how the dynamics of the rRNA dictate the order in which multiple proteins assemble on the 5′ domain of the E. coli 16S rRNA.

    • Sanjaya C. Abeysirigunawardena
    • Hajin Kim
    • Sarah A. Woodson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Three-colour fluorescence resonance energy transfer and molecular dynamics simulations are used to study the events occurring early in assembly of the 30S ribosome; within a non-native intermediate S4 ribosomal protein–16S RNA structure, S4 is capable of altering the RNA helix dynamics to facilitate conformation changes that enable subsequent protein binding.

    • Hajin Kim
    • Sanjaya C. Abeysirigunawarden
    • Sarah A. Woodson
    Research
    Nature
    Volume: 506, P: 334-338

  • Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA unloading activity and forms structurally distinct intermediates compared to RFC-PCNA.

    • Mi-Sun Kang
    • Eunjin Ryu
    • Kyungjae Myung
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Conformational dynamics during the early stage of transcription is crucial to understanding the regulation of transcription efficiency and fidelity. Here the authors, by single-molecule fluorescence resonance energy transfer approaches, examine the conformational dynamics of the two-component transcription system of yeast mitochondria with single-base resolution.

    • Byeong-Kwon Sohn
    • Urmimala Basu
    • Hajin Kim
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Avoiding nonspecific binding is essential for performing fluorescence microscopy–based analyses of single molecules tethered to surfaces. A dichlorodimethylsilane–Tween-20–passivated surface provides a useful alternative to the standard poly(ethylene glycol) surface for single-molecule studies.

    • Boyang Hua
    • Kyu Young Han
    • Taekjip Ha
    Research
    Nature Methods
    Volume: 11, P: 1233-1236