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Showing 1–4 of 4 results

Advanced filters: Author: Hakwoo Lee Clear advanced filters

Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

Aparicio and colleagues identify gene expression changes in breast cancer datasets putatively associated with age-related endocrine effects, suggesting that patient age may influence the prognostic potential of certain biomarkers.

Tomo Osako
Hakwoo Lee
Samuel Aparicio
Research11 May 2020
Nature Cancer

Volume: 1, P: 518-532
Single-cell genomic variation induced by mutational processes in cancer

Single-cell whole-genome sequencing shows that 'foreground' cell-to-cell structural variation and alterations in copy number are associated with genomic diversity and evolution in triple-negative breast and high-grade serous ovarian cancers.

Tyler Funnell
Ciara H. O’Flanagan
Samuel Aparicio
ResearchOpen Access26 Oct 2022
Nature

Volume: 612, P: 106-115
Clonal fitness inferred from time-series modelling of single-cell cancer genomes

Whole-genome sequencing of human cancer cells in patient-derived mouse xenograft models indicates a key role for TP53 in determining the fitness landscape of polyclonal cancer cell populations.

Sohrab Salehi
Farhia Kabeer
Sohrab P. Shah
Research23 Jun 2021
Nature

Volume: 595, P: 585-590
Manipulating disorder within cathodes of alkali-ion batteries

Disorder can be used as a design parameter to improve the electrochemical performance of cathode materials. In this Review, the advantages of disorder engineering are highlighted by revisiting cathode materials and the chemical interactions that lead to different types of disorder.

Seongkoo Kang
Suwon Lee
Yong-Mook Kang
Reviews02 Jul 2024
Nature Reviews Chemistry

Volume: 8, P: 587-604