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New insights into interstitial cystitis and chronic pelvic pain syndromes

In 2016, immunohistochemical evidence revealed major differences in the inflammatory characteristics of Hunner and non-Hunner interstitial cystitis/bladder pain syndrome (IC/BPS). Evidence has also emerged that an isomer of testosterone, etio-S, might be a urinary biomarker of IC/BPS. Intravesical botulinum toxin injections became a standard treatment of IC/BPS. Furthermore, the International Continence Society has published a new Standard for Terminology for Chronic Pelvic Pain Syndromes.

Jia-Fong Jhang
Hann-Chorng Kuo
News & Views29 Nov 2016
Nature Reviews Urology

Volume: 14, P: 69-70
Urodynamic prognostic factors for large post-void residual urine volume after intravesical injection of onabotulinumtoxinA for overactive bladder

Sheng-Mou Hsiao
Ho-Hsiung Lin
Hann-Chorng Kuo
ResearchOpen Access06 Mar 2017
Scientific Reports

Volume: 7, P: 1-7
Purine nucleoside phosphorylase as a target for the treatment of interstitial cystitis/bladder pain syndrome with and without Hunner lesions

Lori A. Birder
Amanda Wolf-Johnston
Edwin K. Jackson
ResearchOpen Access19 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Risk factors of video urodynamics and bladder management for long-term complications in patients with chronic spinal cord injury

Yu-Chen Chen
Hann-Chorng Kuo
ResearchOpen Access02 Jun 2024
Scientific Reports

Volume: 14, P: 1-6
OnabotulinumtoxinA Urethral Sphincter Injection as Treatment for Non-neurogenic Voiding Dysfunction – A Randomized, Double-Blind, Placebo-Controlled Study

Yuan-Hong Jiang
Chung-Cheng Wang
Hann-Chorng Kuo
ResearchOpen Access13 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Current and potential urological applications of botulinum toxin A

Botulinum toxin A (BoNT-A) is an approved treatment of neurogenic and idiopathic overactive bladder, and is also widely used for off-label treatment of a range of other lower urinary tract dysfunctions. Here, authors describe the effectiveness, safety and tolerability of intravesical BoNT-A injections as a treatment of a wide range of urological conditions.

Yuan-Hong Jiang
Chun-Hou Liao
Hann-Chorng Kuo
Reviews11 Aug 2015
Nature Reviews Urology

Volume: 12, P: 519-533
Therapeutic efficacy of biofeedback pelvic floor muscle exercise in women with dysfunctional voiding

Ching-Hsiang Chiang
Yuan-Hong Jiang
Hann-Chorng Kuo
ResearchOpen Access02 Jul 2021
Scientific Reports

Volume: 11, P: 1-8
Difference in electron microscopic findings among interstitial cystitis/bladder pain syndrome with distinct clinical and cystoscopic characteristics

Yu Khun Lee
Jia-Fong Jhang
Hann-Chorng Kuo
ResearchOpen Access26 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection

Ping-Jui Lee
Yuan-Hong Jiang
Hann-Chorng Kuo
ResearchOpen Access08 Mar 2021
Scientific Reports

Volume: 11, P: 1-7
Identifying occult bladder outlet obstruction in women with detrusor-underactivity-like urodynamic profiles

Po-Ming Chow
Sheng-Mou Hsiao
Hann-Chorng Kuo
ResearchOpen Access01 Dec 2021
Scientific Reports

Volume: 11, P: 1-7
Cystoscopic hydrodistention characteristics provide clinical and long-term prognostic features of interstitial cystitis after treatment

Wan-Ru Yu
Jia-Fong Jhang
Hann-Chorng Kuo
ResearchOpen Access11 Jan 2021
Scientific Reports

Volume: 11, P: 1-9
Change of Detrusor Contractility in Patients with and without Bladder Outlet Obstruction at Ten or More Years of follow-up

Sheng-Fu Chen
Cheng-Ling Lee
Hann-Chorng Kuo
ResearchOpen Access11 Dec 2019
Scientific Reports

Volume: 9, P: 1-6
Dysregulation of bladder corticotropin-releasing hormone receptor in the pathogenesis of human interstitial cystitis/bladder pain syndrome

Jia-Fong Jhang
Lori A. Birder
Hann-Chorng Kuo
ResearchOpen Access16 Dec 2019
Scientific Reports

Volume: 9, P: 1-8
Videourodynamic Studies of Women with Voiding Dysfunction

Sheng-Mou Hsiao
Ho-Hsiung Lin
Hann-Chorng Kuo
ResearchOpen Access28 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Do repeat injections of botulinum toxin type A for detrusor overactivity lead to resistance?

Hann-Chorng Kuo
Comments & Opinion01 Sept 2005
Nature Clinical Practice Urology

Volume: 2, P: 414-415
Pathophysiology and potential multimodal therapeutic strategies for IC/BPS

Here, the authors describe current understanding of the pathophysiology of interstitial cystitis/bladder pain syndrome and potential clinical phenotyping based on clinical examinations. They propose a rational algorithm for concomitant multimodal therapy that could help physicians to select appropriate multimodal treatment strategies.

Jia-Fong Jhang
Wan-Ru Yu
Hann-Chorng Kuo
Reviews15 May 2025
Nature Reviews Urology

Volume: 22, P: 672-686
Repeated intravesical injections of platelet-rich plasma improve symptoms and alter urinary functional proteins in patients with refractory interstitial cystitis

Yuan-Hong Jiang
Yuh-Chen Kuo
Hann-Chorng Kuo
ResearchOpen Access16 Sept 2020
Scientific Reports

Volume: 10, P: 1-8
Diagnostic and prognostic value of urine biomarkers among women with dysfunctional voiding

Yuan-Hong Jiang
Jia-Fong Jhang
Hann-Chorng Kuo
ResearchOpen Access22 Apr 2022
Scientific Reports

Volume: 12, P: 1-8
Urine biomarkers in ESSIC type 2 interstitial cystitis/bladder pain syndrome and overactive bladder with developing a novel diagnostic algorithm

Yuan-Hong Jiang
Jia-Fong Jhang
Hann-Chorng Kuo
ResearchOpen Access13 Jan 2021
Scientific Reports

Volume: 11, P: 1-9
Smaller bladder capacity and stronger bladder contractility in patients with ketamine cystitis are associated with elevated TRPV1 and TRPV4

Hsueh-Hui Yang
Jia-Fong Jhang
Hann-Chorng Kuo
ResearchOpen Access04 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Therapeutic outcome of active management in male patients with detrusor underactivity based on clinical diagnosis and videourodynamic classification

Cheng-Ling Lee
Jia-Fong Jhang
Hann-Chorng Kuo
ResearchOpen Access10 Jan 2022
Scientific Reports

Volume: 12, P: 1-9

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