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Showing 1–4 of 4 results
Advanced filters: Author: Hanna Thorsson Clear advanced filters

  • The clinical outcomes and treatment responses of acute myeloid leukemia (AML) patients are heterogeneous. Here, the authors use bulk and single-cell sequencing approaches and identify two transcriptomic subtypes within NPM1-mutated AML with distinct immune evasion properties and responses to hematopoietic stem cell transplantation.

    • Henrik Lilljebjörn
    • Pablo Peña-Martínez
    • Thoas Fioretos
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Clonal evolution and heterogeneity has strong implications for treatment response in acute myeloid leukemia. Here, the authors use patient derived in vivo modelling to highlight the complex clonal and evolutionary dynamics underpinning acute myeloid leukemia progression.

    • Carl Sandén
    • Henrik Lilljebjörn
    • Thoas Fioretos
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • The Cancer Genome Atlas Network describe their multifaceted analyses of primary breast cancers, shedding light on breast cancer heterogeneity; although only three genes (TP53, PIK3CA and GATA3) are mutated at a frequency greater than 10% across all breast cancers, numerous subtype-associated and novel mutations were identified.

    • Daniel C. Koboldt
    • Robert S. Fulton
    • Jacqueline D. Palchik
    ResearchOpen Access
    Nature
    Volume: 490, P: 61-70