Nature Search

Brain insulin sensitivity is linked to adiposity and body fat distribution

Brain insulin action regulates eating behavior and whole-body energy fluxes, however the impact of brain insulin resistance on long-term weight and body fat composition is unknown. Here, the authors show that high brain insulin sensitivity is linked to weight loss during lifestyle intervention and associates with a favorable body fat distribution.

Stephanie Kullmann
Vera Valenta
Martin Heni
ResearchOpen Access15 Apr 2020
Nature Communications

Volume: 11, P: 1-6
Prevention of type 2 diabetes through prediabetes remission without weight loss

A post hoc analysis of a multicentre, randomised trial showed that prediabetes remission is possible without total weight loss—providing weight is distributed to subcutaneous deposits as opposed to visceral ones.

Arvid Sandforth
Elsa Vazquez Arreola
Reiner Jumpertz von Schwartzenberg
ResearchOpen Access29 Sept 2025
Nature Medicine

Volume: 31, P: 3330-3340
Author Correction: Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing

Francesco Volta
M. Julia Scerbo
Jantje M. Gerdes
Amendments and CorrectionsOpen Access03 Aug 2021
Nature Communications

Volume: 12, P: 1
Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show that follistatin regulates insulin-induced suppression lipolysis in cultured human adipocytes.

Chuanyan Wu
Yan Borné
Yang De Marinis
ResearchOpen Access10 Nov 2021
Nature Communications

Volume: 12, P: 1-10
Reduced insulin clearance is linked to subclinical atherosclerosis in individuals at risk for type 2 diabetes mellitus

Elko Randrianarisoa
Angela Lehn-Stefan
Martin Heni
ResearchOpen Access31 Dec 2020
Scientific Reports

Volume: 10, P: 1-8
Slow deep breathing modulates cardiac vagal activity but does not affect peripheral glucose metabolism in healthy men

Andreas Vosseler
Dongxing Zhao
Martin Heni
ResearchOpen Access13 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men

Andreas Vosseler
Dongxing Zhao
Martin Heni
ResearchOpen Access24 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Soluble urokinase receptor (suPAR) predicts microalbuminuria in patients at risk for type 2 diabetes mellitus

Martina Guthoff
Robert Wagner
Nils Heyne
ResearchOpen Access16 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146

Robert Wagner
Jia Li
Rainer Lehmann
ResearchOpen Access13 Jun 2014
Scientific Reports

Volume: 4, P: 1-5
Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies

Róbert Wagner
Ádám G. Tabák
Martin Heni
ResearchOpen Access14 Nov 2017
Scientific Reports

Volume: 7, P: 1-7
Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing

Primary cilia have been proposed to regulate glucose metabolism and insulin secretion in beta cells, but it is not known how. Here the authors show that primary cilia play a role in adult β-cell function via a mechanism involving endosomal EphA-processing.

Francesco Volta
M. Julia Scerbo
Jantje M. Gerdes
ResearchOpen Access12 Dec 2019
Nature Communications

Volume: 10, P: 1-17
Identification of genetic elements in metabolism by high-throughput mouse phenotyping

The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory gene networks and metabolic traits in human GWAS.

Jan Rozman
Birgit Rathkolb
Martin Hrabe de Angelis
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-16
The impact of insulin resistance on the kidney and vasculature

Renal and vascular insulin resistance results in pathophysiological alterations including sodium retention, renal gluconeogenesis and podocyte dysfunction. Here, the authors discuss the mechanisms and effects of insulin resistance in the kidney and vasculature as well as therapeutic approaches to improve insulin sensitivity.

Ferruh Artunc
Erwin Schleicher
Hans-Ulrich Häring
Reviews17 Oct 2016
Nature Reviews Nephrology

Volume: 12, P: 721-737
Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans

Norbert Stefan
Hans-Ulrich Häring
Correspondence04 Apr 2013
Nature Medicine

Volume: 19, P: 394-395
The role of hepatokines in metabolism

In this Review the authors describe the hepatokines—proteins secreted from the liver that directly regulate metabolic processes. They discuss the role of hepatokines in the pathogenesis of type 2 diabetes mellitus and cardiovascular disease. Possible ways in which research in this area could be used to improve screening or in drug development are also touched upon.

Norbert Stefan
Hans-Ulrich Häring
Reviews22 Jan 2013
Nature Reviews Endocrinology

Volume: 9, P: 144-152
Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase

In young women, brain insulin action enhances peripheral insulin sensitivity, but only during the follicular phase of the menstrual cycle. This effect is absent in the luteal phase, possibly due to hypothalamic insulin resistance.

Julia Hummel
Charlotte Benkendorff
Martin Heni
ResearchOpen Access21 Sept 2023
Nature Metabolism

Volume: 5, P: 1475-1482
Impaired insulin action in the human brain: causes and metabolic consequences

In this Review, Martin Heni and colleagues outline the effects of insulin in the brain in humans and the relevance of the effects for physiology. The metabolic consequences of brain insulin resistance are discussed and possible future approaches to overcome brain insulin resistance and thereby prevent or treat obesity and type 2 diabetes mellitus are outlined.

Martin Heni
Stephanie Kullmann
Hans-Ulrich Häring
Reviews13 Oct 2015
Nature Reviews Endocrinology

Volume: 11, P: 701-711
Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

Clustering of patients with prediabetes using simple clinical features reveals six distinct groups with differing risk of developing type 2 diabetes and its associated complications.

Robert Wagner
Martin Heni
Andreas Fritsche
Research04 Jan 2021
Nature Medicine

Volume: 27, P: 49-57
Identification of proliferative and mature β-cells in the islets of Langerhans

Mature pancreatic β-cells can be distinguished from proliferating ones by expression of the Fltp reporter gene, which is triggered by Wnt signalling and β-cell polarization and islet compaction.

Erik Bader
Adriana Migliorini
Heiko Lickert
Research11 Jul 2016
Nature

Volume: 535, P: 430-434
T-helper-1-cell cytokines drive cancer into senescence

T-helper-1-cell cytokines tumour necrosis factor and interferon-γ are shown to drive tumour cells into senescence in a mouse model of β-cell carcinoma and human carcinoma cells.

Heidi Braumüller
Thomas Wieder
Martin Röcken
Research03 Feb 2013
Nature

Volume: 494, P: 361-365
Metabolic implications of pancreatic fat accumulation

There is growing evidence that fat accumulation in the pancreas can have consequences for metabolic health. This Review discusses the methods for detecting pancreatic fat and the potential causes and pathogenic consequences of pancreatic fat accumulation.

Robert Wagner
Sabine S. Eckstein
Martin Heni
Reviews20 Oct 2021
Nature Reviews Endocrinology

Volume: 18, P: 43-54
Acylated- and unacylated ghrelin during an oral glucose tolerance test in humans at risk for type 2 diabetes mellitus

Magnus Wolf
Martin Heni
Andreas Peter
ResearchOpen Access07 Jul 2023
International Journal of Obesity

Volume: 47, P: 825-832
Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight

Lore Wagner
Ralf Veit
Stephanie Kullmann
ResearchOpen Access17 Jun 2022
International Journal of Obesity

Volume: 46, P: 1662-1670
Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation

Julia Hummel
Louise Fritsche
Martin Heni
ResearchOpen Access17 Aug 2021
Scientific Reports

Volume: 11, P: 1-9
FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

Estela Lorza-Gil
Gabriele Kaiser
Susanne Ullrich
ResearchOpen Access05 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
Increased mitochondrial respiration of adipocytes from metabolically unhealthy obese compared to healthy obese individuals

Anja Böhm
Michaela Keuper
Andras Franko
ResearchOpen Access24 Jul 2020
Scientific Reports

Volume: 10, P: 1-10
Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans

Stefan Z. Lutz
Mathias Falcenberg
Konstantinos Kantartzis
ResearchOpen Access17 May 2018
Scientific Reports

Volume: 8, P: 1-10
Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention

Katarzyna Linder
Caroline Willmann
Róbert Wagner
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Glucose, adrenaline and palmitate antagonistically regulate insulin and glucagon secretion in human pseudoislets

Estela Lorza-Gil
Felicia Gerst
Susanne Ullrich
ResearchOpen Access16 Jul 2019
Scientific Reports

Volume: 9, P: 1-11
Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin

Laura Stirm
Peter Huypens
Harald Staiger
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-12
The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells

Christoph Hoffmann
Selina Höckele
Cora Weigert
ResearchOpen Access15 Jan 2018
Scientific Reports

Volume: 8, P: 1-12
Muscle and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in mice

Miriam Hoene
Jia Li
Cora Weigert
ResearchOpen Access26 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice

Andras Franko
Diana C. Rodriguez Camargo
Martin Hrabě de Angelis
ResearchOpen Access18 Jan 2018
Scientific Reports

Volume: 8, P: 1-12
Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

Stephanie Kullmann
Martin Heni
Hubert Preissl
ResearchOpen Access09 May 2017
Scientific Reports

Volume: 7, P: 1-10
Purity matters: A workflow for the valid high-resolution lipid profiling of mitochondria from cell culture samples

Lisa Kappler
Jia Li
Miriam Hoene
ResearchOpen Access19 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans

Elko Randrianarisoa
Angela Lehn-Stefan
Norbert Stefan
ResearchOpen Access27 May 2016
Scientific Reports

Volume: 6, P: 1-9
Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones

S Kaltenbach
H Staiger
H-U Häring
Research12 Apr 2005
International Journal of Obesity

Volume: 29, P: 760-765
Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin

Laura Stirm
Peter Huypens
Harald Staiger
Amendments and CorrectionsOpen Access26 Apr 2022
Scientific Reports

Volume: 12, P: 1-2

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