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Showing 1–8 of 8 results
Advanced filters: Author: Hanson Zhen Clear advanced filters

  • Many premalignant colorectal polyps in familial adenomatous polyposis arise polyclonally rather than from a single mutated cell, showing diverse early evolutionary trajectories that frequently occur without clonal APC or KRAS driver events.

    • Debra Van Egeren
    • Ryan O. Schenck
    • Christina Curtis
    ResearchOpen Access
    Nature
    P: 1-8

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Characterization of Gibbin, encoded by AHDC1, offers insights into the epidermal and mesodermal patterning phenotypes seen in Xia–Gibbs and related syndromes in humans, which derive from abnormal mesoderm maturation as a result of gene-specific DNA methylation decisions.

    • Ann Collier
    • Angela Liu
    • Anthony E. Oro
    Research
    Nature
    Volume: 606, P: 188-196

  • Ivona Aksentijevich and colleagues identify heterozygous loss-of-function mutations in TNFAIP3 (encoding A20) in six unrelated families with early-onset systemic inflammation. Affected individuals exhibit increased expression of NF-κB–mediated proinflammatory cytokines, consistent with the established role of A20 as a potent inhibitor of the NF-κB signaling pathway.

    • Qing Zhou
    • Hongying Wang
    • Ivona Aksentijevich
    Research
    Nature Genetics
    Volume: 48, P: 67-73