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Showing 1–7 of 7 results
Advanced filters: Author: Haoquan Liu Clear advanced filters

  • VRK Serine/Threonine Kinase 2 (VRK2) has shown to play a significant role in apoptosis, cell growth, and immune response. Here the authors report that VRK2 is a key regulator of hepatocellular carcinoma (HCC) which can enhance myelocytomatosis oncogene (MYC) protein stability and transcriptional activity resulting in HCC progression when expressed increased levels

    • Chen Su
    • Zhibin Liao
    • Bixiang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • Understanding RNA regulation mechanisms is crucial for developing targeted therapies for diseases and elucidating how cells control gene expression. This study presents a physics-informed machine learning framework to investigate dynamic regulatory mechanisms in RNA complexes, which when applied to the P-TEFb/Tat/TAR system involved in HIV-1 transcriptional activation and the aaRS/tRNA system essential for genetic translation, outperforms existing methods for uncovering latent regulatory networks.

    • Haoquan Liu
    • Yanan Zhu
    • Yunjie Zhao
    ResearchOpen Access
    Communications Physics
    Volume: 9, P: 1-10

  • Understanding water oxidation on Mn-based catalysts remains a long-standing challenge. Here, the authors use homologous KMnPO4 and KMnPO4•H2O as model catalyst to show that Mn(V)=O is responsible for O−O bond formation and its concentration determines the intrinsic activity.

    • Shujiao Yang
    • Kaihang Yue
    • Wei Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Through a proteomics approach, Qi and colleagues and Long and colleagues identify the sensor of the unfolded protein response IRE1α as an endogenous substrate of the E3 ubiquitin ligase involved in ER-associated degradation, Hrd1.

    • Shengyi Sun
    • Guojun Shi
    • Ling Qi
    Research
    Nature Cell Biology
    Volume: 17, P: 1546-1555

  • The selective formation of Markovnikov products in carbonylation reactions is a challenging problem, especially from unactivated substrates. Now, a highly Markovnikov-selective alkoxycarbonylation reaction is described using a catalyst system based on palladium and the cataCXium ligand POMeCy(Ph). The resulting branched carboxylates are important structural components in many flavour and fragrance products.

    • Haoquan Li
    • Kaiwu Dong
    • Matthias Beller
    Research
    Nature Chemistry
    Volume: 8, P: 1159-1166

  • This study has developed a new method to predict RNA-protein interactions by combining graph neural networks and unsupervised large language models. The model showed superior performances by benchmark tests, especially for previously unseen RNAs and proteins.

    • Haoquan Liu
    • Yiren Jian
    • Yunjie Zhao
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-14