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Showing 1–7 of 7 results
Advanced filters: Author: Harald Hartweger Clear advanced filters

  • Mucida and colleagues developed Tracking Recently Activated Cell Kinetics (TRACK) mice, which allow spatial and temporal labeling of recently activated CD4⁺ T cells. Using these mice, they show that, during influenza infection, tissue-specific environments drive both divergent CD4⁺ T cell differentiation and clonal selection.

    • Roham Parsa
    • Helder C. Assis
    • Daniel Mucida
    Research
    Nature Immunology
    Volume: 27, P: 725-737

  • Germinal centre B cells modify their mutation rate to preserve high-affinity receptors, thereby safeguarding high-affinity B cell lineages and enhancing the outcomes of antibody affinity maturation.

    • Julia Merkenschlager
    • Andrew G. T. Pyo
    • Michel C. Nussenzweig
    ResearchOpen Access
    Nature
    Volume: 641, P: 495-502

  • T cell antigen receptor stimulation by the ligand antigen triggers multiple downstream pathways that affect CD4 + T cell function. Here authors show that activation of the downstream WNK1 kinase causes water entry into the cells, which is essential for CD4+ T cell proliferation.

    • Joshua Biggs O’May
    • Lesley Vanes
    • Victor L. J. Tybulewicz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Although rare, antibodies against the receptor-binding domain of SARS-CoV-2 that showed potent antiviral activity were obtained from all tested convalescent individuals, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.

    • Davide F. Robbiani
    • Christian Gaebler
    • Michel C. Nussenzweig
    Research
    Nature
    Volume: 584, P: 437-442

  • T follicular helper cells undergo antigen-dependent selection in germinal centres, with higher-affinity T cell receptors supporting stronger proliferation leading to their clonal dominance.

    • Julia Merkenschlager
    • Shlomo Finkin
    • Michel C. Nussenzweig
    Research
    Nature
    Volume: 591, P: 458-463

  • Reprogramming of antibody responses in mice is achieved via adeno-associated virus delivery of SaCas9, single guide RNA (sgRNA) and a repair template targeting immunoglobulin genes.

    • Harald Hartweger
    • Michel C. Nussenzweig
    News & Views
    Nature Biotechnology
    Volume: 40, P: 1183-1184

  • Structure determination of glycosylated HIV-1 envelope (Env) trimers complexed with broadly neutralizing antibodies (bNAbs) promotes a better understanding of bNAb epitopes. Here the authors present the structures of natively-glycosylated Env in complex with the highly-potent bNAb BG18, which is of interest for HIV-1 vaccine development.

    • Christopher O. Barnes
    • Harry B. Gristick
    • Pamela J. Bjorkman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12