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Showing 1–2 of 2 results
Advanced filters: Author: Heankel Lyons Clear advanced filters

  • Transcriptional condensates, which are formed through dynamic multivalent interactions between proteins, RNA and chromatin, regulate transcription by compartmentalizing its machinery in the crowded nuclear environment. These condensates regulate animal and plant development, cell signalling and responses to the environment, and they are dysregulated in developmental disorders, cancer and neurodegeneration.

    • Gaofeng Pei
    • Heankel Lyons
    • Benjamin R. Sabari
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 213-236

  • Condensates composed of the disordered region of the mediator of RNA polymerase II transcription subunit 1 (MED1) are known to partition specific proteins, but whether this specificity arises from ordered-structure-mediated or dynamic multivalent amino acid interactions remains unclear. Here, the authors show that a physics-based model that only accounts for multivalent polymer interactions is able to explain and predict selective partitioning, suggesting that the specificity of condensate composition is underpinned by multivalent interactions in the context of conformational disorder.

    • Jonas Wessén
    • Nancy De La Cruz
    • Benjamin R. Sabari
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-15