Nature Search

The Biomarkers Consortium: 20 years of advancing precision medicine

The Foundation for the National Institutes of Health Biomarkers Consortium is celebrating two decades of advancing biomarker science to enable earlier interventions, personalized medicine and improved outcomes in disease prevention, detection, diagnosis and treatment.

Amanda Klein
Jeffrey Siegel
John A. Wagner
Comments & Opinion29 Jan 2026
Nature Reviews Drug Discovery
A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma

Pilcher et al. present a single-cell transcriptomics-based immune atlas of participants with newly diagnosed multiple myeloma, reporting on the association of cell types, gene expression and intercellular interactions with disease progression phenotypes.

William C. Pilcher
Lijun Yao
Manoj Bhasin
ResearchOpen Access09 Jan 2026
Nature Cancer

Volume: 7, P: 224-246
Incident type 2 diabetes attributable to suboptimal diet in 184 countries

Modeling analysis from the Global Dietary Database estimated that 70% of new global cases of type 2 diabetes are attributable to suboptimal intake of 11 dietary factors, with substantial differences in dietary risks across world regions and nations.

Meghan O’Hearn
Laura Lara-Castor
Rubina Hakeem
ResearchOpen Access17 Apr 2023
Nature Medicine

Volume: 29, P: 982-995
Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Laura Lara-Castor
Meghan O’Hearn
Rubina Hakeem
ResearchOpen Access06 Jan 2025
Nature Medicine

Volume: 31, P: 552-564
Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Longitudinal genomic and transcriptomic profiling of 1,143 patients with multiple myeloma by the Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile study yields an improved copy number and gene expression subtype scheme, most notably a high-risk proliferative subtype associated with complete loss of RB1 or MAX.

Sheri Skerget
Daniel Penaherrera
Jonathan J. Keats
ResearchOpen Access19 Aug 2024
Nature Genetics

Volume: 56, P: 1878-1889
Extramedullary disease but not paraskeletal disease portends inferior outcomes after CAR T cell therapy in multiple myeloma

Darren Pan
Tarek H. Mouhieddine
Shambavi Richard
Research03 May 2025
Bone Marrow Transplantation

Volume: 60, P: 1114-1119
Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma

How the immune response is involved in the response to multiple myeloma after treatment is not fully understood. Here the authors investigate how lenalidomide treatment in newly diagnosed MM patients affects the immune microenvironment in the blood and bone marrow and compare between responses to treatment.

David G. Coffey
Francesco Maura
Ola Landgren
ResearchOpen Access02 Sept 2023
Nature Communications

Volume: 14, P: 1-12
The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma

The genetic factors involved in disease progression and drug resistance in multiple myeloma (MM) are varied and complex. Here, genomic and transcriptomic profiling of 511 relapsed and refractory MM patients reveals genetic alterations in several oncogenic pathways contributing to progression and resistance to MM therapies.

Josh N. Vo
Yi-Mi Wu
Arul M. Chinnaiyan
ResearchOpen Access29 Jun 2022
Nature Communications

Volume: 13, P: 1-13
Author Correction: Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Sheri Skerget
Daniel Penaherrera
Jonathan J. Keats
Amendments and CorrectionsOpen Access09 Jun 2025
Nature Genetics

Volume: 57, P: 1789
Clinical response and pathway-specific correlates following TIGIT–LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial

Richard et al. perform a clinical trial of anti-TIGIT (T cell immunoreceptor) or anti-LAG3 (lymphocyte activation gene) antibody in combination with pomalidomide and dexamethasone in persons with multiple myeloma and define correlates of response using mass cytometry.

Shambavi Richard
Alexander M. Lesokhin
Madhav V. Dhodapkar
Research26 Aug 2024
Nature Cancer

Volume: 5, P: 1459-1464
Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism

Hearn Jay Cho
Kenji Takabayashi
Eyal Raz
Research01 May 2000
Nature Biotechnology

Volume: 18, P: 509-514
Author Correction: Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries

Laura Lara-Castor
Meghan O’Hearn
Rubina Hakeem
Amendments and CorrectionsOpen Access28 Jan 2025
Nature Medicine

Volume: 31, P: 696
Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma

William Pilcher
Beena E. Thomas
Manoj Bhasin
ResearchOpen Access26 Jan 2023
npj Genomic Medicine

Volume: 8, P: 1-18
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Bridging advanced myeloma patients to subsequent treatments and clinical trials with classical chemotherapy and stem cell support

Tarek H. Mouhieddine
Erin Moshier
Joshua Richter
Research19 Oct 2022
Bone Marrow Transplantation

Volume: 58, P: 80-86
Coming down from the trees: Is terrestrial activity in Bornean orangutans natural or disturbance driven?

Marc Ancrenaz
Rahel Sollmann
Andreas Wilting
ResearchOpen Access13 Feb 2014
Scientific Reports

Volume: 4, P: 1-5
A phase 1b dose-escalation/expansion study of BET inhibitor RO6870810 in patients with advanced multiple myeloma

Karthik Ramasamy
Ajay Nooka
Hearn Jay Cho
CorrespondenceOpen Access03 Sept 2021
Blood Cancer Journal

Volume: 11, P: 1-3
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Beyond consolidation: auto-SCT and immunotherapy for plasma cell myeloma

N Lendvai
A D Cohen
H J Cho
Reviews09 Mar 2015
Bone Marrow Transplantation

Volume: 50, P: 770-780

Search

Filter By:

Search

Quick links