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Advanced filters: Author: Heike Krebber Clear advanced filters

CPF-CF-terminated snoRNAs shuttle through the cytoplasm via an mRNA guard protein-mediated surveillance mechanism

snoRNAs are synthesized and function in the nucleus, but some of them shuttle into the cytoplasm. This study reveals that the mode of transcription, specifically CPF-CF termination, determines whether the snoRNA is exported.

Fei Yu
Gianluca Zaccagnini
Heike Krebber
ResearchOpen Access06 Mar 2026
Nature Communications

Volume: 17, P: 1-19
mRNA quality control is bypassed for immediate export of stress-responsive transcripts

Heat shock drives the expression of transcripts that bypass mRNA quality control for direct export and translation, allowing cells to survive extreme situations at the cost of accuracy.

Gesa Zander
Alexandra Hackmann
Heike Krebber
Research12 Dec 2016
Nature

Volume: 540, P: 593-596
dsRNA formation leads to preferential nuclear export and gene expression

Antisense RNAs boost gene expression by accelerating the export of mRNA from the nucleus to the cytoplasm through the Dbp2-mediated formation of double-stranded RNAs, which might explain the prevalence of antisense RNAs.

Ivo Coban
Jan-Philipp Lamping
Heike Krebber
ResearchOpen Access19 Jun 2024
Nature

Volume: 631, P: 432-438
Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1

In eukaryotic cells, export of unprocessed pre-mRNAs is prevented by the nuclear surveillance machinery. Here Hackmann et al.identify the SR proteins Gbp2 and Hrb1 as two novel quality control factors for spliced mRNAs that determine their degradation or nuclear export.

Alexandra Hackmann
Haijia Wu
Heike Krebber
Research23 Jan 2014
Nature Communications

Volume: 5, P: 1-14
Unraveling the stepwise maturation of the yeast telomerase including a Cse1 and Mtr10 mediated quality control checkpoint

Anna Greta Hirsch
Daniel Becker
Heike Krebber
ResearchOpen Access12 Nov 2021
Scientific Reports

Volume: 11, P: 1-18