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Showing 1–10 of 10 results
Advanced filters: Author: Helder Maiato Clear advanced filters

  • Metaphase chromosomes oscillate while attached to growing and shrinking microtubules. Here, the authors show that an α-tubulin detyrosination gradient on kinetochore microtubules fine-tunes load-bearing attachments during chromosome oscillations.

    • Hugo Girão
    • Joana Macário-Monteiro
    • Helder Maiato
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Multipolar spindles are a feature of cancer cells often associated with chromosomal aberrations. In the final Review in our Series on Genomic Instability, Logarinho and Maiato discuss how multipolar spindles form, with an emphasis on the role of the loss of spindle pole integrity in this process.

    • Helder Maiato
    • Elsa Logarinho
    Reviews
    Nature Cell Biology
    Volume: 16, P: 386-394

  • The formation of a bipolar spindle is critical for accurate segregation of the genome. Maiato and colleagues now demonstrate that CLASPs (cytoplasmic linker associated proteins) prevent spindle multipolarity in a manner independent of end-on kinetochore–microtubule attachments. They propose that CENP-E-mediated traction forces are balanced by CLASP-mediated recruitment of ninein to centriolar satellites.

    • Elsa Logarinho
    • Stefano Maffini
    • Helder Maiato
    Research
    Nature Cell Biology
    Volume: 14, P: 295-303

  • Kinetochores form the critical interface with spindle microtubules that accounts for chromosome movement and segregation fidelity during mitosis. Spatial and temporal control of motor protein and checkpoint signaling at kinetochores is now possible with a new set of optogenetic tools.

    • Ana C Figueiredo
    • Helder Maiato
    News & Views
    Nature Chemical Biology
    Volume: 13, P: 1058-1059

  • Centriolar separation is thought to be crucial for centriole duplication, but the mechanism behind separation is poorly understood. Here, using micropatterning, the authors report that actomyosin forces influence the direction, distance, and time of centriole separation.

    • Elisa Vitiello
    • Philippe Moreau
    • Martial Balland
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Using electron and three-dimensional structured illumination microscopy methods, Jana et al. characterize the ciliary base in four different cilia types in Drosophila, discovering structural and protein component differences that may be linked to the diversified functions of cilia.

    • Swadhin Chandra Jana
    • Susana Mendonça
    • Mónica Bettencourt-Dias
    Research
    Nature Cell Biology
    Volume: 20, P: 928-941

  • Epithelial cells must position their mitotic spindle correctly to maintain cell–cell adhesion. Here Vitiello et al. show that the tumour suppressor DLC2 and the mitotic kinesin Kif1b coordinate microtubule–actin interactions upstream of mDia3, guiding spindle positioning and mitotic fidelity.

    • Elisa Vitiello
    • Jorge G. Ferreira
    • Karl Matter
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-15

  • In most eukaryotes, the centromere is defined by epigenetic marks such as the histone H3 variant CENH3/CENP-A/CID. Ectopic induction of kinetochores in Drosophila S2 cells by CID overexpression leads to kinetochore assembly specifically in silent intergenic regions bordering heterochomratin, demonstrating a role for these domains in centromere identity.

    • Agata M. Olszak
    • Dominic van Essen
    • Patrick Heun
    Research
    Nature Cell Biology
    Volume: 13, P: 799-808