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Showing 1–12 of 12 results
Advanced filters: Author: Hendrik Jan Thibaut Clear advanced filters

  • The chimeric candidate Zika virus vaccine YF-ZIK has been previously shown to confer protection in mice after a single dose regimen. Here the authors further characterise the response to YF-ZIK and show induction of immunity and protection in non-human primates.

    • Ji Ma
    • Bert Malengier-Devlies
    • Kai Dallmeier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe lung injury, playing a dual role in SARS-CoV-2 infection.

    • Robbert Boudewijns
    • Hendrik Jan Thibaut
    • Kai Dallmeier
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • A candidate vaccine against SARS-CoV-2 that uses the yellow fever 17D live-virus vector is highly efficacious and displays a favourable safety profile in Syrian hamster, mouse and cynomolgus macaque models.

    • Lorena Sanchez-Felipe
    • Thomas Vercruysse
    • Kai Dallmeier
    Research
    Nature
    Volume: 590, P: 320-325

  • The adipose-specific phospholipase A2 (PLA2G16) has been identified as a pan-enterovirus host factor. Here, the authors show that the enterovirus EV-D68-947 can bypass PLA2G16 by using sulfated glycosaminoglycans as alternative glycan receptors and that the interaction induces structural changes promoting viral genome release.

    • Jim Baggen
    • Yue Liu
    • Frank J. M. van Kuppeveld
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • In recent years, several non-polio enteroviruses (NPEVs) have emerged as serious public health concerns. In this Review, van Kuppeveld and colleagues summarize recent insights from enterovirus research, with a special emphasis on NPEVs, and reflect on how recent discoveries may help in the development of new antiviral strategies.

    • Jim Baggen
    • Hendrik Jan Thibaut
    • Frank J. M. van Kuppeveld
    Reviews
    Nature Reviews Microbiology
    Volume: 16, P: 368-381

  • Currently licensed COVID-19 vaccines are based on antigen sequences of early SARS-CoV-2 isolates, despite the prevalence of variants of concerns escaping vaccine-mediated protection. Using their updated yellow fever 17D vectored candidate, here, authors assess neutralising antibody responses against variants of concern, and demonstrate protection and reduced transmission in a hamster model.

    • Sapna Sharma
    • Thomas Vercruysse
    • Kai Dallmeier
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Antiviral approaches against entire genera or families of viruses need to be constantly developed and innovated. Focusing on several distantly-related orthoflaviviruses, the authors develop a cell-based multiplex antiviral assay for high-throughput screening against multiple viruses at once.

    • Li-Hsin Li
    • Winston Chiu
    • Kai Dallmeier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.

    • César Muñoz-Fontela
    • William E. Dowling
    • Dan H. Barouch
    Reviews
    Nature
    Volume: 586, P: 509-515