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Routine blood tests and machine learning identify complications in high myopia

Authors develop a machine learning model using routine blood tests that identify people at higher risk of complications from high myopia. Their results support opportunistic screening during health checks to enable earlier referral.

Shengjie Li
Jun Ren
Meiyan Li
ResearchOpen Access14 Mar 2026
Nature Communications

P: 1-19
Large-scale screening of blinding eye diseases from routine blood tests

A blood-based signature is shown to detect blinding disease risk and discriminate among seven different diseases in multiple cohorts including more than 200,000 individuals, including prospective and population-level cohorts.

Shengjie Li
Jun Ren
Xingtao Zhou
Research06 Apr 2026
Nature Health

P: 1-15
A noninvasive machine learning model using a complete blood count for screening of primary vitreoretinal lymphoma

Primary vitreoretinal lymphoma (PVRL) is a rare and aggressive intraocular malignancy that is frequently misdiagnosed. Here, the authors conduct a multicentre case‒control study to develop a machine learning–based screening model for PVRL diagnosis from complete blood count data, with validation in large-scale clinical cohorts.

Shengjie Li
Jiazhen Cao
Wenjun Cao
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-11
Dbh⁺ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart

Catecholaminergic transmitters are critical signalling effectors known to be released by sympathetic nerves and adrenomedullary endocrine cells in response to physiological stress. In this paper, the authors demonstrate a uniquely distributed group of catecholaminergic cardiomyocytes with key regulatory roles in cardiac excitation conduction.

Tianyi Sun
Alexander Grassam-Rowe
Ming Lei
ResearchOpen Access28 Nov 2023
Nature Communications

Volume: 14, P: 1-23

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Routine blood tests and machine learning identify complications in high myopia

Large-scale screening of blinding eye diseases from routine blood tests

A noninvasive machine learning model using a complete blood count for screening of primary vitreoretinal lymphoma

Dbh+ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart

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Dbh⁺ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart