Nature Search

Apatinib plus ifosfamide and etoposide versus ifosfamide and etoposide in patients with advanced osteosarcomas (OAIE/PKUPH-sarcoma 11): a randomized phase II study

In patients with metastatic osteosarcoma who have progressed on first-line chemotherapy, the prognosis is poor. Here, the authors report a phase II randomized clinical trial comparing the combination of apatinib (multi tyrosine kinase inhibitor) and chemotherapy (ifosfamide and etoposide) against chemotherapy alone in patients with relapsed or refractory metastatic osteosarcoma.

Lu Xie
Jie Xu
Xiaodong Tang
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-9
Dalpiciclib or placebo plus fulvestrant in hormone receptor-positive and HER2-negative advanced breast cancer: a randomized, phase 3 trial

In the multicenter, phase 3 DAWNA-1 trial, the combination of dalpiciclib, a new cyclin-dependent kinase 4 and 6 inhibitor, with fulvestrant, in patients with HR⁺HER2⁻ advanced breast cancer who progressed or relapsed on endocrine therapy, improved progression-free survival with manageable safety and may represent a new treatment option.

Binghe Xu
Qingyuan Zhang
Jianjun Zou
Research04 Nov 2021
Nature Medicine

Volume: 27, P: 1904-1909
Discovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy

Qiyue Hu
Xin Ye
Weikang Tao
ResearchOpen Access16 May 2018
Scientific Reports

Volume: 8, P: 1-11
A multicenter phase 2 trial of camrelizumab plus famitinib for women with recurrent or metastatic cervical squamous cell carcinoma

Patients with recurrent or metastatic cervical cancer have limited therapeutic options. Here the authors report efficacy and safety of camrelizumab (anti-PD-1 antibody) in combination with famitinib (anti-angiogenic agent) in pre-treated recurrent or metastatic squamous cervical cancer.

Lingfang Xia
Qi Zhou
Xiaohua Wu
ResearchOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1-9
Discovery of novel non-retroviral endogenous viral elements reveals their long-term integration history in spiders

Endogenous viral elements have influenced the evolution of numerous species. Through structure prediction and sequence analysis, this study reveals a novel group of endogenous nuclear arthropod large DNA virus sequences integrated within spider genomes.

Hengrui Hu
Just M. Vlak
Manli Wang
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-13
SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study

Ziming Li
Zhengbo Song
Shun Lu
ResearchOpen Access15 Jul 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-10
Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis

Suxing Liu
Dong Liu
Weikang Tao
ResearchOpen Access28 Apr 2021
Scientific Reports

Volume: 11, P: 1-12
Formation of 4′-carboxyl acid metabolite of imrecoxib by rat liver microsomes

Hai-yan Xu
Peng Zhang
Da-fang Zhong
Research01 Apr 2006
Acta Pharmacologica Sinica

Volume: 27, P: 506-512
Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma

The characterisation of the papillary thyroid carcinoma (PTC) tumour microenvironment remains crucial. Here, the authors perform single-cell RNA sequencing in 11 patients and identify potential opportunities for the use of immunotherapy and its combination with anti-angiogenic therapy in PTC.

Weilin Pu
Xiao Shi
Yu-Long Wang
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-18
Relay learning: a physically secure framework for clinical multi-site deep learning

Zi-Hao Bo
Yuchen Guo
Qionghai Dai
ResearchOpen Access04 Nov 2023
npj Digital Medicine

Volume: 6, P: 1-11
FINO₂ initiates ferroptosis through GPX4 inactivation and iron oxidation

FINO₂ is a small molecule that requires the endoperoxide moiety and hydroxyl group to promote ferroptosis through indirect inhibition of GPX4 enzymatic function and direct oxidation of iron, resulting in increased lipid peroxidation.

Michael M. Gaschler
Alexander A. Andia
Brent R. Stockwell
Research02 Apr 2018
Nature Chemical Biology

Volume: 14, P: 507-515
Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial

Yi-Zhou Jiang
Yin Liu
Zhi-Ming Shao
ResearchOpen Access27 Jul 2020
Cell Research

Volume: 31, P: 178-186
Mucin-like protein of Crimean-Congo hemorrhagic fever virus is a key virulence factor and a potent target for developing novel attenuated vaccine

Liushuai Li
Yajie Liu
Manli Wang
Correspondence16 May 2025
Cell Research

Volume: 35, P: 524-527
FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection

Hao Meng
Zhiying Liao
Huisheng Liu
ResearchOpen Access23 Apr 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries

Yongbing Pan
Jianhui Du
Xiaoming Yang
ResearchOpen Access27 Jul 2021
Cell Discovery

Volume: 7, P: 1-19
Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq

Bing He
Shuning Liu
Yao-Qing Chen
ResearchOpen Access17 May 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-12
Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NFκB signaling

Daniel A. C. Fisher
Cathrine A. Miner
Stephen T. Oh
Research04 Feb 2019
Leukemia

Volume: 33, P: 1978-1995
Infection of human sweat glands by SARS-CoV-2

Jia Liu
Yufeng Li
Manli Wang
CorrespondenceOpen Access13 Nov 2020
Cell Discovery

Volume: 6, P: 1-3
Quantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities

Ya-ting Zhou
Jia-hui Chu
Chen Zhao
ResearchOpen Access15 Feb 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1287-1304
Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

Jia Liu
Ruiyuan Cao
Manli Wang
CorrespondenceOpen Access18 Mar 2020
Cell Discovery

Volume: 6, P: 1-4
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro

Xi Wang
Ruiyuan Cao
Manli Wang
CorrespondenceOpen Access02 May 2020
Cell Discovery

Volume: 6, P: 1-5

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