The Birch reduction, although widely used and effective, suffers from significant limitations in the available nucleophiles, since in most cases only alkyl halides and silyl chlorides are available. Herein, the authors report a Birch reductive arylation by mechanochemical anionic activation using a lithium(0) wire followed by addition of various fluoroarenes.
- Yoshifumi Toyama
- Akiko Yagi
- Hideto Ito
