Multiple DNA damage resulting from different nearby ionizations of water molecules is an important process of the initial step of radiobiological effects, however, the DNA damage process is not well characterized. Here, the authors develop a dynamic Monte Carlo code to quantitatively calculate the yields of DNA damage clustering, suggesting a hydroxyl radical and a hydrated electron from a single spur can concomitantly react within a 10 base pairs DNA to induce a multiple DNA damage site comprising a DNA single-strand break and reductive nucleobase damage.
- Takeshi Kai
- Tomohiro Toigawa
- Akinari Yokoya
