The construction of self-assembled nanogels with oligonucleotide double strands as the association points was achieved by grafting short-chain (4-mer and 6-mer) oligonucleotides containing bridged nucleic acids (BNA), an artificial nucleic acid, onto polysaccharides. The oligonucleotide-grafted polysaccharides, composed of oligonucleotides with varying chain lengths, sequences, and BNA substitution numbers, formed nanogels in water, and their aggregation behavior was found to change with temperature.
- Shin-ichi Sawada
- Hirokazu Iwamoto
- Kazunari Akiyoshi
