Nature Search

Tryptophanase disruption promotes insect–bacterium mutualism

Disruption of a single gene encoding tryptophanase makes Escherichia coli mutualistic in a stinkbug model owing to the accumulation of tryptophan and a reduction in toxic indole. This gene is typically lacking in symbionts of wild stinkbugs.

Yayun Wang
Minoru Moriyama
Takema Fukatsu
ResearchOpen Access27 Feb 2026
Nature Microbiology

Volume: 11, P: 759-769
Clinical importance of the range of detectable variants between the Oncomine Dx target test and a conventional single-gene test for EGFR mutation

Tadashi Sakaguchi
Akemi Iketani
Osamu Hataji
ResearchOpen Access23 Aug 2023
Scientific Reports

Volume: 13, P: 1-7
Daily steps are associated with walking ability in hospitalized patients with sub-acute stroke

Hiroki Kubo
Masashi Kanai
Shinichi Shimada
ResearchOpen Access17 Jul 2022
Scientific Reports

Volume: 12, P: 1-8
MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis

How β-AR signaling coordinates epigenetic and transcriptional pathways is unknown. Here the authors show that cold-induced β-AR signaling negatively regulates MYPT1-PP1β phosphatase activity to orchestrate both pathways for beige adipogenesis.

Hiroki Takahashi
Ge Yang
Juro Sakai
ResearchOpen Access29 Sept 2022
Nature Communications

Volume: 13, P: 1-19
Highly porous nature of a primitive asteroid revealed by thermal imaging

Thermal imaging data obtained from the spacecraft Hayabusa2 reveal that the carbonaceous asteroid 162173 Ryugu is an object of unusually high porosity.

Tatsuaki Okada
Tetsuya Fukuhara
Yuichi Tsuda
Research16 Mar 2020
Nature

Volume: 579, P: 518-522
Drug Release OFF Behavior and Deswelling Kinetics of Thermo-Responsive IPNs Composed of Poly(acrylamide-co-butyl methacrylate) and Poly(acrylic acid)

Hiroki Katono
Kohei Sanui
Yasuhisa Sakurai
Research01 Oct 1991
Polymer Journal

Volume: 23, P: 1179-1189
Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch

JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose tissue-driven thermogenesis requires β-adrenergic dependent phosphorylation of S265 but is independent of H3K9me2 demethylation.

Yohei Abe
Yosuke Fujiwara
Juro Sakai
ResearchOpen Access19 Apr 2018
Nature Communications

Volume: 9, P: 1-16
MUCIN 1 confers inflammatory memory of tyrosine kinase inhibitor resistance in non-small cell lung cancer

Shinkichi Takamori
Naoki Haratake
Donald Kufe
ResearchOpen Access28 Nov 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-16
Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial

Yuichi Saito
Atsushi Tanaka
Kosuke Nishio
Research14 Nov 2023
Hypertension Research

Volume: 47, P: 168-176
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis

How enhancers transition from a hypoacetylated primed state to a hyperacetylated-active state in response to differentiation stimuli is incompletely understood. Here the authors show that SETD5 forms a complex with NCoR-HDAC3 co-repressor to prevent histone acetylation of master adipogenic gene enhancers, while SETD5 degradation triggers enhancer hyperacetylation and transition to active state.

Yoshihiro Matsumura
Ryo Ito
Juro Sakai
ResearchOpen Access02 Dec 2021
Nature Communications

Volume: 12, P: 1-19
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Combined stimuli of elasticity and microgrooves form aligned myotubes that characterize slow twitch muscles

Hiroki Hamaguchi
Tomoko G. Oyama
Mitsumasa Taguchi
ResearchOpen Access08 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Blood pressure reduction with empagliflozin in Japanese patients with type 2 diabetes and cardiovascular diseases: a post-hoc sub-analysis of the placebo-controlled randomized EMBLEM trial

Atsushi Tanaka
Michio Shimabukuro
Kunio Yufu
Research24 May 2024
Hypertension Research

Volume: 47, P: 2295-2302
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Canagliflozin independently reduced plasma volume from conventional diuretics in patients with type 2 diabetes and chronic heart failure: a subanalysis of the CANDLE trial

Kazuki Shiina
Hirofumi Tomiyama
Akiomi Yoshihisa
Research15 Nov 2022
Hypertension Research

Volume: 46, P: 495-506
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

Mice that lack the fission mitochondrial GTPase Drp1, are shown to die during embryonic development. Although Drp1 is not required for apoptosis, the absence of Drp1 leads to neuronal and synaptic defects due to a failure of elongated mitochondria to reach distal parts of axons.

Naotada Ishihara
Masatoshi Nomura
Katsuyoshi Mihara
Research05 Jul 2009
Nature Cell Biology

Volume: 11, P: 958-966
Newborn Cerebrovascular Responses after First Trimester Moderate Maternal Ethanol Exposure in Sheep

Christine A Gleason
Hiroki Iida
Richard J Traystman
Research01 Jul 1997
Pediatric Research

Volume: 42, P: 39-45
Mathematical mechanistic model representing the cancer immunity cycle under radiation effects

Taisuke Takayanagi
Koichi Miyazaki
Kenji Chamoto
ResearchOpen Access06 Jun 2025
Scientific Reports

Volume: 15, P: 1-14
Radiogenomics for predicting p53 status, PD-L1 expression, and prognosis with machine learning in pancreatic cancer

Yosuke Iwatate
Isamu Hoshino
Wataru Takayama
ResearchOpen Access21 Jul 2020
British Journal of Cancer

Volume: 123, P: 1253-1261
Relationship between neutropenia caused by nanoliposomal irinotecan/fluorouracil/leucovorin and treatment outcomes in the NAPOLEON-2 study (NN-2301)

Tomonori Araki
Yuki Sonoda
Kenji Mitsugi
ResearchOpen Access27 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
Author Correction: Daily steps are associated with walking ability in hospitalized patients with sub-acute stroke

Hiroki Kubo
Masashi Kanai
Shinichi Shimada
Amendments and CorrectionsOpen Access23 Aug 2022
Scientific Reports

Volume: 12, P: 1
Nanoliposomal irinotecan with fluorouracil and folinic acid, FOLFIRINOX, and S-1 as second-line treatment for unresectable pancreatic cancer after gemcitabine/nab-paclitaxel

Taro Shibuki
Taiga Otsuka
Kenji Mitsugi
ResearchOpen Access23 Jul 2024
Scientific Reports

Volume: 14, P: 1-10
Northern Hemisphere winter atmospheric teleconnections are intensified by extratropical ocean-atmosphere coupling

Extratropical atmosphere-ocean coupling enhances the variability of the three main modes of winter climate variability in the Northern Hemisphere by modulating the energy balance, according to coupled and uncoupled large ensemble global model simulations over the period 1979-2020.

Masato Mori
Yu Kosaka
Hisashi Nakamura
ResearchOpen Access15 Mar 2024
Communications Earth & Environment

Volume: 5, P: 1-16
A multicenter retrospective observational NAPOLEON2 study of nanoliposomal irinotecan with fluorouracil and folinic acid in patients with unresectable pancreatic cancer

Tomoko Kodama
Takashi Imajima
Kenji Mitsugi
ResearchOpen Access30 May 2024
Scientific Reports

Volume: 14, P: 1-10
Efficacy of second-line chemotherapy after treatment with gemcitabine plus nab-paclitaxel or FOLFIRINOX in patients with metastatic pancreatic cancer

Masaru Fukahori
Yoshinobu Okabe
Tsuyoshi Shirakawa
ResearchOpen Access08 Nov 2023
Scientific Reports

Volume: 13, P: 1-10
C-reactive protein/albumin ratio is the most significant inflammatory marker in unresectable pancreatic cancer treated with FOLFIRINOX or gemcitabine plus nab-paclitaxel

Tsuyoshi Shirakawa
Akitaka Makiyama
Eishi Baba
ResearchOpen Access31 May 2023
Scientific Reports

Volume: 13, P: 1-12
Close-to-lesion transbronchial biopsy: a novel technique to improve suitability of specimens for genetic testing in patients with peripheral pulmonary lesions

Yoichi Nishii
Tadashi Sakaguchi
Osamu Hataji
ResearchOpen Access07 Sept 2023
Scientific Reports

Volume: 13, P: 1-11
Pressure pain threshold map of thoracolumbar paraspinal muscles after lengthening contractions in young male asymptomatic volunteers

Kohei Hanada
Hiroki Ota
Toru Taguchi
ResearchOpen Access22 Sept 2022
Scientific Reports

Volume: 12, P: 1-12
Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department

Mototaka Inaba
Hiromichi Naito
Kaoru Masuda
ResearchOpen Access03 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin

Ken Arae
Masashi Ikutani
Susumu Nakae
ResearchOpen Access15 Mar 2021
Scientific Reports

Volume: 11, P: 1-12
Interleukin-27 controls basal pain threshold in physiological and pathological conditions

Tomoko Sasaguri
Toru Taguchi
Toshiharu Yasaka
ResearchOpen Access23 Jul 2018
Scientific Reports

Volume: 8, P: 1-13
Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster

Higashijima et al show that mice lacking the Kdm7a demethylase exhibits anterior homeotic transformation of the axial skeleton and downregulation of posterior Hox gene transcription and these changes are associated with increased H3K9me2 at posterior Hox loci. These findings provide insights into the epigenetic control of Hox-mediated patterning in embryogenesis.

Yoshiki Higashijima
Nao Nagai
Yasuharu Kanki
ResearchOpen Access30 Nov 2020
Communications Biology

Volume: 3, P: 1-11
Effectiveness of plasma lyso-Gb3 as a biomarker for selecting high-risk patients with Fabry disease from multispecialty clinics for genetic analysis

Hiroki Maruyama
Kaori Miyata
Satoshi Ishii
ResearchOpen Access15 Mar 2018
Genetics in Medicine

Volume: 21, P: 44-52
Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex

Hirobumi Tada
Tomoyuki Miyazaki
Takuya Takahashi
ResearchOpen Access16 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
Amendments and CorrectionsOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1
Author Correction: C-reactive protein/albumin ratio is the most significant inflammatory marker in unresectable pancreatic cancer treated with FOLFIRINOX or gemcitabine plus nab-paclitaxel

Tsuyoshi Shirakawa
Akitaka Makiyama
Eishi Baba
Amendments and CorrectionsOpen Access04 Mar 2024
Scientific Reports

Volume: 14, P: 1
Validation of the obesity paradox by body mass index and waist circumference in patients undergoing percutaneous coronary intervention

Yuichiro Shirahama
Noriaki Tabata
Junichi Matsubara
Research28 Jul 2022
International Journal of Obesity

Volume: 46, P: 1840-1848
Correction: Effectiveness of plasma lyso-Gb3 as a biomarker for selecting high-risk patients with Fabry disease from multispecialty clinics for genetic analysis

Hiroki Maruyama
Kaori Miyata
Satoshi Ishii
Amendments and Corrections07 Sept 2018
Genetics in Medicine

Volume: 21, P: 512-515
Correction: Effectiveness of plasma lyso-Gb3 as a biomarker for selecting high-risk patients with Fabry disease from multispecialty clinics for genetic analysis

Hiroki Maruyama
Kaori Miyata
Satoshi Ishii
Amendments and Corrections06 Feb 2019
Genetics in Medicine

Volume: 21, P: 1263
Correction: Effectiveness of plasma lyso-Gb3 as a biomarker for selecting high-risk patients with Fabry disease from multispecialty clinics for genetic analysis

Hiroki Maruyama
Kaori Miyata
Satoshi Ishii
Amendments and CorrectionsOpen Access12 Sept 2018
Genetics in Medicine

Volume: 21, P: 1900

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