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Scientific Reports (33)
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Showing 1–50 of 115 results

Advanced filters: Author: Hiroshi Hamada Clear advanced filters

Potential Z-DNA forming sequences are highly dispersed in the human genome

Hiroshi Hamada
Takeo Kakunaga
Research22 Jul 1982
Nature

Volume: 298, P: 396-398
Mid-term systolic BP variability beyond 24 h after successful recanalization predicts poor outcomes following ischemic stroke

Yuki Hamada
Hideki Matsuoka
Hiroshi Takashima
Research13 Mar 2026
Hypertension Research

Volume: 49, P: 1610-1620
In vivo imaging analyses to explore the integration of multimodal aversive sensory information in the central amygdala

Xinliang Zhou
Yuta Sakuragi
Masabumi Minami
ResearchOpen Access23 Dec 2025
Scientific Reports

Volume: 15, P: 1-6
Carrier cell-mediated cell lysis of squamous cell carcinoma by squamous cell carcinoma antigen 1 promoter-driven oncolytic adenovirus

Katsuyuki Hamada
Ting Zhang
Hiroyuki Hamakawa
ResearchOpen Access08 May 2009
Nature Precedings

P: 1
Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos

Chikara Meno
Yukio Saijoh
Hiroshi Hamada
Research09 May 1996
Nature

Volume: 381, P: 151-155
Pseudohomozygous type II hyperlipoproteinemia

Keisuke Hamada
Tomoko Tanaka
Hiroshi Mabuchi
Research20 Jun 2005
Japanese journal of human genetics

Volume: 27, P: 259-264
Integrative epigenome and transcriptome analyses reveal transcriptional programs differentially regulated by ASCL1 and NEUROD1 in small cell lung cancer

Hiroshi Takumida
Akira Saito
Masafumi Horie
ResearchOpen Access01 Jul 2025
Oncogene

Volume: 44, P: 3113-3125
Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Masamichi Yamamoto
Yukio Saijoh
Chikara Meno
Research07 Mar 2004
Nature

Volume: 428, P: 387-392
Author Correction: Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial

Tien Dam
Adam L. Boxer
Theresa Zesiewicz
Amendments and Corrections17 Oct 2022
Nature Medicine

Volume: 29, P: 2955-2956
Nodal paralogues underlie distinct mechanisms for visceral left–right asymmetry in reptiles and mammals

Left–right symmetry in vertebrates is established during development by different mechanisms, including motile cilia. Here, the authors show asymmetric expression of a Nodal paralogue in the left–right organizer in two reptilian embryos, which do not have motile cilia.

Eriko Kajikawa
Uzuki Horo
Hiroshi Hamada
Research06 Jan 2020
Nature Ecology & Evolution

Volume: 4, P: 261-269
Caprazamycins, Novel Lipo-nucleoside Antibiotics, from Streptomyces sp.

Masayuki Igarashi
Yoshiaki Takahashi
Yuzuru Akamatsu
Research01 May 2005
The Journal of Antibiotics

Volume: 58, P: 327-337
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Detection of MspI RFLP in human THY1 gene by the polymerase chain reaction

Jian Fu
Hiroshi Ikegami
Toshio Ogihara
Research01 Sept 1995
Japanese journal of human genetics

Volume: 40, P: 279-280
Photoelectron Holographic Atomic Arrangement Imaging of Cleaved Bimetal-intercalated Graphite Superconductor Surface

Fumihiko Matsui
Ritsuko Eguchi
Yoshihiro Kubozono
ResearchOpen Access04 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

Akinori Kimura
Haruhito Harada
Takehiko Sasazuki
Research01 Aug 1997
Nature Genetics

Volume: 16, P: 379-382
Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer

Desmoplastic stroma is a hallmark of aggressive colorectal cancer. Matrix cancer-associated fibroblasts derived THBS2 establishes a fibrotic, immune-exclusionary barrier that limits CD8⁺ T cell infiltration, while its inhibition restores CXCR3-mediated T cell recruitment and enhances response to immune checkpoint blockade.

Kosuke Iwane
Yuki Nakanishi
Hiroshi Seno
ResearchOpen Access23 Nov 2025
Nature Communications

Volume: 16, P: 1-20
Conversion of Human Colonic Adenoma Cells to Adenocarcinoma Cells Through Inflammation in Nude Mice

Futoshi Okada
Tokuichi Kawaguchi
Masuo Hosokawa
Research01 Nov 2000
Laboratory Investigation

Volume: 80, P: 1617-1628
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Questioning what regulates left-right asymmetry breaking in the mouse node: the authors identify a 200 bp stretch of the Dand5 3’UTR where Bicc1 binds, and Cnot proteins downstream of calcium flow regulate the post-transcriptional regulation of Dand5 by Bicc1.

Katsura Minegishi
Benjamin Rothé
Hiroshi Hamada
ResearchOpen Access01 Jul 2021
Nature Communications

Volume: 12, P: 1-17
Reply to Comment on “Lower high-density lipoprotein cholesterol level is associated with hematoma expansion in acute intracerebral hemorrhage: association with hypertensive microangiopathy”

Takeo Sato
Yuka Tsuchimochi
Hiroshi Takashima
Correspondence27 Feb 2026
Hypertension Research

Volume: 49, P: 1790-1791
Bio-essential sugars in samples from asteroid Bennu

Samples returned from asteroid Bennu contain bio-essential sugars such as ribose and glucose that may have formed in the parent asteroid from brines containing formaldehyde, according to a geochemical study.

Yoshihiro Furukawa
Sako Sunami
Dante S. Lauretta
ResearchOpen Access02 Dec 2025
Nature Geoscience

Volume: 19, P: 19-24
Establishment of vertebrate left–right asymmetry

Hiroshi Hamada
Chikara Meno
Yukio Saijoh
Reviews01 Feb 2002
Nature Reviews Genetics

Volume: 3, P: 103-113
Prevalence of common aneuploidy in twin pregnancies

Akiko Konishi
Osamu Samura
Haruhiko Sago
ResearchOpen Access01 Jan 2022
Journal of Human Genetics

Volume: 67, P: 261-265
Observation of Phase Transition of Liquid Crystalline Polymers by Ultrasonic Method. (Hydroxypropyl)cellulose and (n-Hexanoyloxypropyl)cellulose

Akira Tanaka
Yorihisa Hamada
Koh-hei Nitta
Research01 May 1994
Polymer Journal

Volume: 26, P: 599-605
Usefulness and safety of new ultrasmall-diameter colonoscope for cases with difficult insertion: a retrospective study

Rie Terada
Ryoji Ichijima
Hirofumi Kogure
ResearchOpen Access14 Sept 2024
Scientific Reports

Volume: 14, P: 1-6
Calaxin is required for cilia-driven determination of vertebrate laterality

Keita Sasaki, Kogiku Shiba, Akihiro Nakamura et al. show that mice lacking calaxin have intact fertility despite showing primary cilia dyskinesia and abnormal 9 + 0 nodal cilia formation, while loss of calaxin in zebrafish causes situs inversus but does not affect 9 + 2 axonemal formation. Together, these findings suggest a specific role for calaxin in 9 + 0 nodal cilia development.

Keita Sasaki
Kogiku Shiba
Kazuo Inaba
ResearchOpen Access20 Jun 2019
Communications Biology

Volume: 2, P: 1-11
Determination of left–right patterning of the mouse embryo by artificial nodal flow

Shigenori Nonaka
Hidetaka Shiratori
Hiroshi Hamada
Research04 Jul 2002
Nature

Volume: 418, P: 96-99
Generation of functional oocytes from male mice in vitro

Mouse induced pluripotent stem cells derived from differentiated fibroblasts could be converted from male (XY) to female (XX), resulting in cells that could form oocytes and give rise to offspring after fertilization.

Kenta Murakami
Nobuhiko Hamazaki
Katsuhiko Hayashi
Research15 Mar 2023
Nature

Volume: 615, P: 900-906
Origin and role of distal visceral endoderm, a group of cells that determines anterior–posterior polarity of the mouse embryo

A combination of genetic fate mapping and imaging reveals that the distal visceral endoderm of mouse embryo arises following the migration of Lefty1-expressing primitive endoderm progenitor already present in the implanting blastocyst.

Katsuyoshi Takaoka
Masamichi Yamamoto
Hiroshi Hamada
Research29 May 2011
Nature Cell Biology

Volume: 13, P: 743-752
Cloning of inv, a gene that controls left/right asymmetry and kidney development

Toshio Mochizuki
Yukio Saijoh
Takahiko Yokoyama
Research10 Sept 1998
Nature

Volume: 395, P: 177-181
Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos

In the mouse embryo, anterior-posterior polarity is established by distal visceral endoderm (DVE) at embryonic day 5.5 but how this arises is unclear. Here, the authors show that expression of Lefty1 earlier can define DVE, and that future DVE cells are selected by Nodal signalling and stochasticity.

Katsuyoshi Takaoka
Hiromi Nishimura
Hiroshi Hamada
ResearchOpen Access14 Nov 2017
Nature Communications

Volume: 8, P: 1-13
Overexpression of Bcl-2 in bladder cancer cells inhibits apoptosis induced by cisplatin and adenoviral-mediated p53 gene transfer

Hideaki Miyake
Norihisa Hanada
Hideyuki Saya
Research03 Mar 1998
Oncogene

Volume: 16, P: 933-943
A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Masaki Okamoto
Kiminori Fujimoto
Tomoaki Hoshino
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
Two rotating cilia in the node cavity are sufficient to break left–right symmetry in the mouse embryo

The left–right asymmetry of an organism is patterned during development and is determined by fluid flow created by the movement of cilia. In this study, the asymmetry is shown to be determined early after the movement of cilia is established and that only two rotating cilia are required for breaking symmetry.

Kyosuke Shinohara
Aiko Kawasumi
Hiroshi Hamada
Research10 Jan 2012
Nature Communications

Volume: 3, P: 1-8
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy

This study identifies TTTCA- and TTTTA-repeat expansions in benign adult familial myoclonic epilepsy. Cortical neurons from affected people exhibit RNA foci containing these expanded repeats, suggesting RNA toxicity as the mechanism underlying disease pathogenesis.

Hiroyuki Ishiura
Koichiro Doi
Shoji Tsuji
Research05 Mar 2018
Nature Genetics

Volume: 50, P: 581-590
In vivo kinematics and cruciate ligament forces in bicruciate-retaining total knee arthroplasty

Kenichi Kono
Hiroshi Inui
Darryl D. D’Lima
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5

The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module.

Markus Maerker
Maike Getwan
Axel Schweickert
ResearchOpen Access16 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Thermodynamic Properties of Atactic Polypropylene Solutions

Hiroshi Ochiai
Toshihiko Ohashi
Ichiro Murakami
Research01 Jun 1982
Polymer Journal

Volume: 14, P: 457-464
Less-invasive fascia-preserving surgery for abdominal wall desmoid

Yoshihiro Nishida
Shunsuke Hamada
Shiro Imagama
ResearchOpen Access29 Sept 2021
Scientific Reports

Volume: 11, P: 1-8
Preparation and Structure of Copper Nanoparticles-polysilane Composite Film

Jun Kamada
Masaki Takahashi
Shoji Tamai
Research14 Sept 2007
Polymer Journal

Volume: 39, P: 1118-1119
Alignment and Micropatterning of Carbon Nanotubes in Polymer Composites Using Modulated Magnetic Field

Guangzhe Piao
Fumiko Kimura
Tsunehisa Kimura
Research23 Apr 2007
Polymer Journal

Volume: 39, P: 589-592
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
The genome sequence and structure of rice chromosome 1

Takuji Sasaki
Takashi Matsumoto
Takashi Gojobori
ResearchOpen Access21 Nov 2002
Nature

Volume: 420, P: 312-316
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

Angiogenesis is involved in compensatory cardiac hypertrophy following pressure overload. However, the process also induces the accumulation of p53 which ultimately suppresses angiogenesis and thereby contributes to the transition from hypertrophy to heart failure.

Masanori Sano
Tohru Minamino
Issei Komuro
Research04 Mar 2007
Nature

Volume: 446, P: 444-448
Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch

The transcription factor Pitx2 induces a dynamic morphological change in the outflow tract of the heart, which results in asymmetric blood supply to the branchial arch artery system. The uneven blood distribution results in differential signalling responses that cause the asymmetric remodelling of the great arteries

Kenta Yashiro
Hidetaka Shiratori
Hiroshi Hamada
Research08 Nov 2007
Nature

Volume: 450, P: 285-288
Wnt signalling escapes to cilia

The primary cilium is proposed to restrain the level of canonical Wnt signalling, but it was unknown how the cilium achieves this. β-catenin, a component of the canonical Wnt signalling pathway, is now shown to be sequestered to the cilium by the Wnt signalling modulator Jouberin (Jbn) to restrain Wnt responses.

Rieko Ajima
Hiroshi Hamada
News & Views01 Jun 2011
Nature Cell Biology

Volume: 13, P: 636-637
THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

Thrombospondin-1 (THBS1) is a matricellular protein highly expressed in inflammatory processes, including cancer. Here the authors show that bone-marrow derived monocyte-like cells are the primary source of THBS1 in colorectal cancer, associated with mesenchymal characteristics, immunosuppression and a poor prognosis.

Mayuki Omatsu
Yuki Nakanishi
Hiroshi Seno
ResearchOpen Access25 Sept 2023
Nature Communications

Volume: 14, P: 1-19
Fluid flow and interlinked feedback loops establish left–right asymmetric decay of Cerl2 mRNA

During embryonic development, midline fluid flow results in asymmetric nodal gene expression. Using genetic manipulations and mathematical modelling, Nakamura et al. find that expression of the nodal antagonist Cerl2 is regulated post-transcriptionally, and that asymmetry is maintained by Wnt-Cerl2 feedback loops.

Tetsuya Nakamura
Daisuke Saito
Hiroshi Hamada
Research27 Dec 2012
Nature Communications

Volume: 3, P: 1-13
Upregulation of epidermal growth factor receptor 4 in oral leukoplakia

Hiroshi Kobayashi
Kenichi Kumagai
Ryuji Suzuki
ResearchOpen Access15 Mar 2013
International Journal of Oral Science

Volume: 5, P: 14-20
Preserved ratio impaired spirometry with or without restrictive spirometric abnormality

Shinichiro Miura
Hiroshi Iwamoto
Noboru Hattori
ResearchOpen Access20 Feb 2023
Scientific Reports

Volume: 13, P: 1-7

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