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Showing 1–50 of 312 results

Advanced filters: Author: Hiroshi Ono Clear advanced filters

Targeted therapy guided by circulating tumor DNA analysis in advanced gastrointestinal tumors

In the observational SCRUM-Japan GOZILA study, after a median follow-up of 11 months, patients with metastatic gastrointestinal tumors who received biomarker-matched therapies based on circulating tumor DNA profiling showed a greater clinical benefit than those receiving unmatched therapy.

Yoshiaki Nakamura
Hiroshi Ozaki
Takayuki Yoshino
ResearchOpen Access16 Sept 2024
Nature Medicine

Volume: 31, P: 165-175
Rates of oxygenation and Bohr shift of capillary blood in chick embryos

HIROSHI TAZAWA
MASAJI MOCHIZUKI
Research10 Jun 1976
Nature

Volume: 261, P: 509-511
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

Masanori Asakura
Masafumi Kitakaze
Shigeki Higashiyama
Research01 Jan 2002
Nature Medicine

Volume: 8, P: 35-40
Glucose Inhibition of the Glucose-sensitive Neurone in the Rat Lateral Hypothalamus

YUTAKA OOMURA
HIROSHI OOYAMA
YASUYUKI YAMADA
Research01 Feb 1974
Nature

Volume: 247, P: 284-286
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase

Activation of cAMP signalling by prostaglandin E₂ (PGE₂) has long been thought to suppress Tcell receptor activation and Th1 cell differentiation. Yao et al. reveal that dual stimulation of both cAMP and PI 3-kinase pathways by PGE₂ synergistically promotes Th1 differentiation by amplifying IL-12 and IFN-γsignalling.

Chengcan Yao
Takako Hirata
Shuh Narumiya
ResearchOpen Access09 Apr 2013
Nature Communications

Volume: 4, P: 1-15
Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases

Tsuyoshi Shuto
Shunsuke Kamei
Hirofumi Kai
ResearchOpen Access16 Dec 2016
Scientific Reports

Volume: 6, P: 1-15
A layered ionic crystal of polar Li@C₆₀ superatoms

Metal-containing fullerene cages are widely known, but hard to characterize because of their reactivity towards empty cages. Now the molecular and crystal structures of lithium-containing C₆₀ molecules have been determined.

Shinobu Aoyagi
Eiji Nishibori
Hiromi Tobita
Research20 Jun 2010
Nature Chemistry

Volume: 2, P: 678-683
Spatial dynamics of CD39⁺CD8⁺ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer

Immune checkpoint blockade (ICB) benefits esophageal squamous cell cancer, but the immune cell mediators remain unclear. Here the author show, by imaging mass cytometry, that CD39⁺CD8⁺ exhausted cells are present abundantly in both tertiary lymphoid tissue and tumor and correlate with responses to ICB.

Kenro Tanoue
Hirofumi Ohmura
Eishi Baba
ResearchOpen Access19 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Electron Microscopy of Islet Alpha Cells of Domestic Fowl

MITSUO MACHINO
HIROSHI SAKUMA
Research20 May 1967
Nature

Volume: 214, P: 808-809
Elastic anisotropy of experimental analogues of perovskite and post-perovskite help to interpret D′′ diversity

Seismological observations of the D′′ layer near the core–mantle boundary are difficult to interpret and the minerals present are unstable at ambient conditions. Yoneda et al.present experiments using analogues, suggesting the observations are due to preferred crystal orientations.

Akira Yoneda
Hiroshi Fukui
Alfred Q. R. Baron
ResearchOpen Access27 Mar 2014
Nature Communications

Volume: 5, P: 1-8
Allylic Polymers V. Electronic Effects of Acyloxy Group in Allyl Chloroacetates on Homopolymerization

Naruhito Ono
Yasumasa Shigetomi
Michinori Oki
Research01 Sept 1992
Polymer Journal

Volume: 24, P: 951-957
Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions

Takumi Mikawa
Masahiro Kameda
Hiroshi Kondoh
ResearchOpen Access15 Dec 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-18
Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer

Shu Yazaki
Rui Kitadai
Kouya Shiraishi
ResearchOpen Access28 Nov 2025
npj Breast Cancer

Volume: 11, P: 1-11
Adjuvant S-1 plus endocrine therapy for ER-positive, HER2-negative, primary breast cancer: post-POTENT trial prognostic survey

Masahiro Takada
Shigehira Saji
Masakazu Toi
ResearchOpen Access24 Oct 2025
npj Breast Cancer

Volume: 11, P: 1-6
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Sulphur isotope evidence for an oxic Archaean atmosphere

Rocks formed before 2.4 Gyr have not been found to contain a mass-independently fractionated sulphur isotopes (MIF-S) chemical signature. This suggests that either atmospheric oxygen levels fluctuated dramatically before 2.4 Gyr, or that MIF-S is not a reliable indictor of when atmospheric oxygen levels were low.

Hiroshi Ohmoto
Yumiko Watanabe
Bruce E. Taylor
Research24 Aug 2006
Nature

Volume: 442, P: 908-911
Prostaglandin E₂ promotes intestinal tumor growth via DNA methylation

This report uncovers a direct link between cancer-driving inflammation and DNA methylation by showing that PGE₂ regulates the expression of DNA methylases, resulting in silencing of tumor-suppressor genes. The authors suggest that DNA methylation is an important component of the pathogenic effect of inflammatory signaling in colorectal cancer.

Dianren Xia
Dingzhi Wang
Raymond N DuBois
Research22 Jan 2012
Nature Medicine

Volume: 18, P: 224-226
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Optical Anisotropy of Photo-Crosslinkable Polymer Film and Photoalignment Control of Nematic Liquid Crystals Using Nonpolarized Ultraviolet Irradiation

Nobuhiro Kawatsuki
Tohei Yamamoto
Hiroshi Ono
Research01 Jul 1999
Polymer Journal

Volume: 31, P: 630-632
Two-barrier stability that allows low-power operation in current-induced domain-wall motion

Controlling magnetic domain wall motion in nanowires requires a thorough knowledge of the depinning mechanisms. Here, the authors show that current-induced intrinsic depinning has a different energy barrier than magnetic field-induced extrinsic depinning, and succeed in quantifying the respective barriers.

Kab-Jin Kim
Ryo Hiramatsu
Teruo Ono
Research17 Jun 2013
Nature Communications

Volume: 4, P: 1-6
Trastuzumab deruxtecan in HER2-positive advanced gastric cancer: exploratory biomarker analysis of the randomized, phase 2 DESTINY-Gastric01 trial

Exploratory analyses of the DESTINY-Gastric01 trial show that baseline HER2-associated biomarkers in circulating tumor DNA or tissue samples were associated with therapeutic response in patients with HER2-positive tumors, and these analyses identify potential drivers of resistance.

Kohei Shitara
Yung-Jue Bang
Kensei Yamaguchi
ResearchOpen Access14 May 2024
Nature Medicine

Volume: 30, P: 1933-1942
Calcitonin gene-related peptide regulates calcium current in heart muscle

Kageyoshi Ono
Michael Delay
Wayne Giles
Research31 Aug 1989
Nature

Volume: 340, P: 721-724
The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan

Sekiya and colleagues identify that, in response to reductive metabolism, CtBP2 is secreted via exosomes and regulates metabolism in recipient cells via CYB5R3 and AMPK. Exosomal CtBP2 administration extends lifespan and healthspan in aged mice, and serum levels of CtBP2 decline with age in humans.

Motohiro Sekiya
Kenta Kainoh
Hitoshi Shimano
Research08 Oct 2025
Nature Aging

Volume: 5, P: 2197-2214
Identification of a receptor for protein import into mitochondria

Debkumar Pain
Hiroshi Murakami
Günter Blobel
Research04 Oct 1990
Nature

Volume: 347, P: 444-449
Plasma amino acid profile is altered by visceral fat accumulation and is a predictor of visceral obesity in humans

Takayuki Tanaka
Yuko Ishizaka
Minoru Yamakado
ResearchOpen Access19 Jan 2011
Nature Precedings

P: 1
Allylic Polymers IV. The Effect of Alkyl-Substituents on Copolymerization of Allyl Alkyl Ethers with Vinyl Acetate

Yasumasa Shigetomi
Naruhito Ono
Michinori Oki
Research01 Mar 1992
Polymer Journal

Volume: 24, P: 247-255
Circulating tumor DNA-guided treatment with pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer: a phase 2 trial

The multicenter phase 2 TRIUMPH trial shows the utility of ctDNA genotyping as a screening platform to select patients with HER2-amplified metastatic colorectal cancer who benefit from dual-HER2 blockade with trastuzumab and pertuzumab

Yoshiaki Nakamura
Wataru Okamoto
Takayuki Yoshino
ResearchOpen Access11 Nov 2021
Nature Medicine

Volume: 27, P: 1899-1903
Shape of the first mitotic spindles impacts multinucleation in human embryos

Defects in cell division occur often in early embryos, though the mechanisms underlying these errors and their correction remain unclear. Here they develop a method for imaging zygotic chromosomes during human zygotic cleavage and find that the spindle shape influences formation of micronuclei.

Yuki Ono
Hiromitsu Shirasawa
Yukihiro Terada
ResearchOpen Access25 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes

Tsuyoshi Akagi
Hiroaki Ono
Kunitada Shimotohno
Research01 May 1997
Oncogene

Volume: 14, P: 2071-2078
IL-17-producing γδ T cells enhance bone regeneration

γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice.

Takehito Ono
Kazuo Okamoto
Hiroshi Takayanagi
ResearchOpen Access11 Mar 2016
Nature Communications

Volume: 7, P: 1-9
ATX-LPA₁ axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation

Tatsuji Nishioka
Naoaki Arima
Junken Aoki
ResearchOpen Access23 Mar 2016
Scientific Reports

Volume: 6, P: 1-15
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Pneumonitis associated with pembrolizumab plus chemotherapy for non-squamous non-small cell lung cancer

Daichi Fujimoto
Satoru Miura
Nobuyuki Yamamoto
ResearchOpen Access06 Mar 2023
Scientific Reports

Volume: 13, P: 1-11
Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

The role of cortical PV neurons in the regulation of sleep architecture and homeostatic sleep rebound is not fully understood. Here, the authors show that CaMKII-mediated control of cortical parvalbumin-neuron activity regulates the homeostatic sleep rebound in mice.

Kazuhiro Kon
Koji L. Ode
Hiroki R. Ueda
ResearchOpen Access18 Jul 2024
Nature Communications

Volume: 15, P: 1-19
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

Taku Okazaki
Yoshimasa Tanaka
Tasuku Honjo
Research02 Nov 2003
Nature Medicine

Volume: 9, P: 1477-1483
Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology

Yasumasa Mitani
Alexander Lezhava
Yoshihide Hayashizaki
Research18 Feb 2007
Nature Methods

Volume: 4, P: 257-262
Different efficacy of tyrosine kinase inhibitors by KIT and PGFRA mutations identified in circulating tumor DNA for the treatment of refractory gastrointestinal stromal tumors

Tadayoshi Hashimoto
Yoshiaki Nakamura
Takayuki Yoshino
ResearchOpen Access25 Jul 2024
BJC Reports

Volume: 2, P: 1-10
Publisher Correction: The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass

Shin Fujimaki
Tomohiro Matsumoto
Yusuke Ono
Amendments and Corrections16 Mar 2022
Nature Metabolism

Volume: 4, P: 404
Urine phospholipid profiling in patients with rheumatoid arthritis and nontuberculous mycobacterial pulmonary disease

Hiroshi Furukawa
Shomi Oka
Shigeto Tohma
ResearchOpen Access13 Oct 2025
Scientific Reports

Volume: 15, P: 1-7
Prostaglandin receptors induce urothelial tumourigenesis as well as bladder cancer progression and cisplatin resistance presumably via modulating PTEN expression

Eiji Kashiwagi
Satoshi Inoue
Hiroshi Miyamoto
ResearchOpen Access09 Nov 2017
British Journal of Cancer

Volume: 118, P: 213-223
Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study

Norio Okada
Shintaro Iwama
Hiroshi Arima
ResearchOpen Access03 Feb 2020
British Journal of Cancer

Volume: 122, P: 771-777
Thermal Decomposition of Cellulose Grafted with Acrylonitrile in a Homogeneous System

Noboru Nishioka
Hiroshi Ono
Masahiro Karasuno
Research01 Apr 1992
Polymer Journal

Volume: 24, P: 301-309
Linearly Polarized Ultraviolet Photoreaction of Poly[6-(4′-cinnamoylbiphenyl-4-yloxy)hexyl methacrylate] and Alignment Behavior of Liquid Crystals on the Resultant Photoreacted Films

Nobuhiro Kawatsuki
Ken Takatani
Hiroshi Ono
Research01 Dec 1998
Polymer Journal

Volume: 30, P: 946-949
Local Chain Dynamics of Poly(N-vinylcarbazole) Studied by the Fluorescence Depolarization Method

Hiroyuki Aoki
Jun-ichi Horinaka
Mitsuo Sawamoto
Research01 Jun 2001
Polymer Journal

Volume: 33, P: 464-468
Construction of a 7-Aminocephalosporanic Acid (7ACA) Biosynthetic Operon and Direct Production of 7ACA in Acremonium Chrysogenum

Takao Isogai
Masao Fukagawa
Hiroshi Imanaka
Research01 Feb 1991
Bio/Technology

Volume: 9, P: 188-191
Components of giant hornet alarm pheromone

Masato Ono
Hirokazu Terabe
Masami Sasaki
Research07 Aug 2003
Nature

Volume: 424, P: 637-638

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