Nucleobase modification of acyclic XNA oligomers achieved functionalization for use as a novel fluorescent probe and photoswitching system. A linear probe, composed of serinol nucleic acid (SNA) and 5-perylenylethynyl uracil residues, enabled quantitative detection of target RNA through a visually observable change in fluorescent color and intensity. A photoresponsive SNA with two 8-pyrenylvinyl adenine (PVA) residues established photocontrol of SNA/RNA duplex formation and dissociation. Using a combination of 8-naphthylvinyl adenine (NVA) and PVA demonstrated orthogonal photocontrol system. Thus, nucleobase modifications further expand the utility of acyclic XNA in bionanotechnology.
- Keiji Murayama
- Yuuhei Yamano
- Hiroyuki Asanuma
