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Showing 1–3 of 3 results
Advanced filters: Author: Hongji Pu Clear advanced filters
  • A probe incorporating 1,024 simultaneously recorded channels with shank length up to 90 mm exhibits high chronic recording stability and enables brain-wide large-scale neural population recordings with single-cell resolution in non-human primates.

    • Yang Liu
    • Huilin Jia
    • Xiaojie Duan
    Research
    Nature Neuroscience
    Volume: 27, P: 1620-1631
  • We developed novel polydopamine (PDA)-modified gelatin methacryloyl (GelMA) hydrogel nanofibers for sustained Secreted Frizzled-Related Protein 2 (SFRP2) release to promote peripheral nerve regeneration and angiogenesis synchronously. In vitro experiments demonstrated that these nanofibers significantly enhanced Schwann cell migration and endothelial cell tube formation. In a mouse model of peripheral nerve injury, the SFRP2-loaded nanofibers effectively promoted angiogenesis, nerve repair, and target muscle restoration via the calcineurin/NFATc3 signaling pathway. These findings suggest a promising therapeutic strategy for peripheral nerve injuries.

    • Linjie Zhang
    • Peng Qiu
    • Minyi Yin
    ResearchOpen Access
    NPG Asia Materials
    Volume: 17, P: 1-19